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公开(公告)号：EP2651938A1
公开(公告)日：2013-10-23
申请号：EP11806096.1
申请日：2011-12-16
发明人： CHARIFSON, Paul, S. , CLARK, Michael P. , BANDARAGE, Upul K. , DENG, Hongbo , DAVIES, Ioana , DUFFY, John P. , FARMER, Luc J. , GAO, Huai , GU, Wenxin , KENNEDY, Joseph, M. , LEDEBOER, Mark, W. , LEDFORD, Brian , MALTAIS, François , PEROLA, Emanuele , WANNAMAKER, Marion W. , WANG, Tiansheng , SALITURO, Francesco, G.
IPC分类号： C07D471/04 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/53
CPC分类号： C07D471/04
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，助剂或媒介物。
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2.发明公开
公开(公告)号：EP3049418A1
公开(公告)日：2016-08-03
申请号：EP14824596.2
申请日：2014-09-25
发明人： FARMER, Luc J. , FOURNIER, Pierre-Andre , LESSARD,Stephanie , LIU, Bingcan , ST-ONGE, Miguel , STURINO, Claudio , SZYCHOWSKI, Janek , YANNOPOULOS, Constantin , VALLEE, Frederic , LACOSTE, Jean-Eric , MARTEL, Julien , RAMTOHUL, Yeeman , SAYEGH, Camil Elie , BUBENIK, Monica
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , C07D519/00
摘要： wherein the variables are as defined herein.
摘要翻译： 其中变量如本文所定义。
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