公开(公告)号：EP2442809B1

公开(公告)日：2016-08-31

申请号：EP10726760.1

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

摘要翻译： 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：EP3141252B8

公开(公告)日：2019-03-13

申请号：EP16181549.3

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

公开(公告)号：EP2442809A1

公开(公告)日：2012-04-25

申请号：EP10726760.1

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven

IPC分类号： A61K31/506 ,  A61P31/16

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.