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    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA
    1.
    发明公开
    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA 有权
    系统和虚拟索引平衡扩散器MEDIA方法

    公开(公告)号：EP2480126A1

    公开(公告)日：2012-08-01

    申请号：EP10776206.4

    申请日：2010-09-22

    申请人： Visen Medical, Inc.

    发明人： RIPOLL, Lorenzo, Jorge ,  YARED, Wael, I. ,  KEMPNER, Joshua

    IPC分类号： A61B5/00 ,  G01N21/47 ,  G06T11/00

    CPC分类号： A61B5/0073 ,  A61B6/037 ,  A61B2562/146 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/1787

    摘要： The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.

    ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES
    2.
    发明公开
    ANIMAL HOLDER FOR IN VIVO TOMOGRAPHIC IMAGING WITH MULTIPLE MODALITIES 有权
    动物HOLDER层析成像与多个方法和程序体内成像

    公开(公告)号：EP2265181A1

    公开(公告)日：2010-12-29

    申请号：EP09724324.0

    申请日：2009-03-25

    申请人： Visen Medical, Inc.

    发明人： YARED, Wael, I. ,  WILSON, Andrew, K.

    IPC分类号： A61B6/04 ,  A61D3/00

    CPC分类号： A61B6/045 ,  A61B5/7285 ,  A61B6/0421 ,  A61B6/485 ,  A61B6/508 ,  A61B6/583 ,  A61B8/543 ,  A61B2503/40

    摘要： The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations. The animal holder optionally also includes a system for providing the animal with inhalation anesthesia, for example, isoflurane, and is designed to fit into identical receptacles inside or outside the imaging workstation(s) that provide heating to minimize or prevent animal hypothermia.

    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA
    4.
    发明授权
    SYSTEMS AND METHODS FOR VIRTUAL INDEX-MATCHING OF DIFFUSIVE MEDIA 有权
    系列VERFAHRENFÜRVIRTUELLEN INDEXABGLEICH DIFFUSER MEDIEN

    公开(公告)号：EP2480126B1

    公开(公告)日：2017-01-04

    申请号：EP10776206.4

    申请日：2010-09-22

    申请人： VisEn Medical, Inc.

    发明人： RIPOLL, Lorenzo, Jorge ,  YARED, Wael, I. ,  KEMPNER, Joshua

    IPC分类号： A61B5/00 ,  G01N21/47 ,  G06T11/00

    CPC分类号： A61B5/0073 ,  A61B6/037 ,  A61B2562/146 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/1787

    摘要： The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.

    摘要翻译： 本发明涉及一种用于通过将受试者的自由空间中获得的电磁辐射（例如，荧光）的测量转换为如果对象被无限的周围被测量将被测量的数据的测量的漫射介质的受试者的层析成像的系统和方法 和均匀扩散介质，例如具有等于受试者的平均光学性质的光学性质的介质。 在应用变换以将测量值转换为虚拟匹配值之后，光的传播从目标匹配表面模拟到对象外部的一组虚拟检测器，并以几何有利的方式布置，例如在平面阵列中， 从而便于使用快速重建技术。

    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGING IN DIFFUSE MEDIA USING A HYBRID INVERSION TECHNIQUE
    5.
    发明公开
    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGING IN DIFFUSE MEDIA USING A HYBRID INVERSION TECHNIQUE 审中-公开
    系统和方法成像弥漫层析介质与混合反演方法

    公开(公告)号：EP2470887A2

    公开(公告)日：2012-07-04

    申请号：EP10807566.4

    申请日：2010-08-27

    申请人： Visen Medical, Inc.

    发明人： RIPOLL LORENZO, Jorge ,  YARED, Wael, I. ,  KEMPNER, Joshua

    IPC分类号： G01N21/64 ,  G06T11/00

    摘要： The invention relates to systems and methods for tomographic imaging in diffuse media employing a fast reconstruction technique. A hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets. In certain embodiments, the invention features methods of in vivo fluorescence molecular tomographic (FMT) reconstruction of signals, reporters and/or agents (i.e., contrast agents or probes) in a diffusive medium (e.g., a mammalian subject). The method preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed, allowing FMT imaging of larger anatomies.