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1.发明公开STERILE POLYMERIZABLE SYSTEMS AND KITS AND METHODS OF THEIR MANUFACTURE AND USE 审中-公开无菌聚合系统和他们的生产和使用装置和方法
公开(公告)号：EP1359944A2
公开(公告)日：2003-11-12
申请号：EP01273524.7
申请日：2001-11-27
IPC分类号： A61L2/00
CPC分类号： A61L2/081 , A61L2/0017 , A61L2/0023 , A61L2/022 , A61L2/04 , A61L2/206 , A61L2202/24
摘要： The present invention overcomes the difficulties in the sterilization and delivery of viscous, multi-component compositions that require pre-mixing prior to usage by disclosing a sterile, multi-component, ready-to-use product wherein each component is sterilized independently and then assembled into a sterilized delivery kit. In certain preferred embodiments of the present invention, a sterile, polimerizable system is provided that comprises a plurality of sterile polymerizable monomers, said monomers having been sterilized by passing them through a filter; at least one sterile filler which has been exposed to conditions effective to render said filler sterile, and the sterile monomers and the sterile filler being blended together to form at least one substantially homogeneous blend contained within a sterile delivery vessel. Still other embodiments include a single-use kit that comprises a delivery gun, mix tips, and cartridges that comprise one or more pastes of the present invention that are housed within one or more pouches to ensure sterility of the internal contents.
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