公开(公告)号：EP2671574A1

公开(公告)日：2013-12-11

申请号：EP12170756.6

申请日：2012-06-04

申请人： VitaK B.V.

发明人： Vermeer, Cornelis ,  De Borst, Martin Hendrik

IPC分类号： A61K31/122 ,  G01N33/49 ,  A61P37/06

CPC分类号： G01N33/68 ,  A61K31/122 ,  A61K31/593 ,  A61K45/06 ,  G01N2333/47 ,  G01N2440/10 ,  G01N2800/52 ,  A61K2300/00

摘要： Circulating uncarboxylated matrix Gla-protein (ucMGP), in particular desphospho-ucMGP, is provided as a prognostic biomarker for allograft failure and mortality in patients who received organ transplantation and who are under immunosuppressive medication. A diagnostic tool is provided to monitor vitamin K status in such patients, i.e. the level of uncarboxylated species of extra-hepatic vitamin K-dependent proteins. Various forms and recommended dosages of vitamin K, optionally combined with vitamin D and/or other immunosuppressive medication, are provided to optimize the treatment of such patients resulting in decreased allograft failure and improved patient survival.

摘要翻译： 循环未羧化的骨钙基质蛋白（ucMGP），特别是desphospho-ucMGP，是谁收到器官移植，谁是下免疫抑制药物的患者提供用于移植失败和死亡的预后标志物。 一种诊断工具被提供给监测患者维生素K状态检查，即 肝外维生素K依赖性蛋白质的未羧基化的物种的水平。 各种形式和推荐的维生素K的剂量，任选地与维生素D和/或其他免疫抑制药物的组合，提供了最优化的寻求减少同种异体移植物衰竭和提高患者存活率得到的患者的治疗。