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公开(公告)号：EP2114386A1
公开(公告)日：2009-11-11
申请号：EP08720107.5
申请日：2008-01-24
IPC分类号： A61K31/00 , A61K31/215 , A61P3/10
CPC分类号： A61K31/00 , A61K31/215
摘要： A method for treating diabetic complications by administration of a beta-blocker is disclosed. Diabetic complications arise from diabetes and have few or no existing treatment options. The present invention describes the use of a beta-blocker in the treatment of a diabetic. The present invention also describes the inhibition of aldose reductase, one of the chief causative factors of diabetic complications. Also provided are methods of diabetic wound healing. Compositions for treating diabetic complications, such as diabetic wounds, are disclosed. The present invention includes employing a topical formulation of a beta-blocker, having substantially no antibacterial activity, to improve the process of diabetic wound healing. The present invention also involves increasing the rate of collagen accumulation of the healing epithelialized tissue in the wound of a diabetic individual.
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公开(公告)号：EP2114386B9
公开(公告)日：2013-09-18
申请号：EP08720107.5
申请日：2008-01-24
IPC分类号： A61K31/00 , A61K31/215 , A61P3/10
CPC分类号： A61K31/00 , A61K31/215
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公开(公告)号：EP2114386B1
公开(公告)日：2012-12-26
申请号：EP08720107.5
申请日：2008-01-24
IPC分类号： A61K31/00 , A61K31/215 , A61P3/10
CPC分类号： A61K31/00 , A61K31/215
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公开(公告)号：EP2480204B1
公开(公告)日：2013-11-06
申请号：EP10803276.4
申请日：2010-09-21
CPC分类号： A61K31/24 , A61K9/0014
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公开(公告)号：EP2480204A2
公开(公告)日：2012-08-01
申请号：EP10803276.4
申请日：2010-09-21
CPC分类号： A61K31/24 , A61K9/0014
摘要： This invention relates to a new topical gel formulation of the drug Esmolol hydrochloride for treatment of chronic wounds such as diabetic wounds, burn wounds, venous ulcers and pressure ulcers.
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