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公开(公告)号：EP0664807B1
公开(公告)日：1997-09-10
申请号：EP93922849.0
申请日：1993-10-08
IPC分类号： C07D471/04 , C07D487/04 , A61K31/495 , A61K31/55 , C07F9/6561 , A61K31/675 , C07D215/40 , C07D215/38 , C07D217/02 , C07D217/04 , C07D209/48
CPC分类号： C07D471/04 , C07D217/04 , C07D487/04 , C07F9/6561
摘要： A compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or hydroxy; R1 is hydrogen, alkyl, arylalkyl, (CH¿2?)nOH or (CH2)nNR?7R8; R5 and R6¿ are each independently hydrogen, halogen, NO¿2?, CN, CF3, SO2NR?7R8, PO¿3R9R10, alkyl, alkenyl, alkynyl, (CH¿2?)nCONR?7R8, (CH¿2)nCO2R?10, NHCOR11¿, wherein R?7 and R8¿ are each independently hydrogen or alkyl or together R?7 and R8¿ form a ring of from three to seven atoms, R9 is hydrogen or alkyl, R10 is hydrogen or alkyl, R11 is hydrogen or alkyl, and n is an integer of from zero to four; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b, and formed by the following bivalent radicals: a-NR?12-CHR13-CHR14¿-b, a-CHR?13-CHR14-NR12¿-b, a-CHR?13-NR12-CHR14¿-b, a-CHR14-CH2-NR?12-CHR13¿-b, a-CHR?13-NR12-CH¿2-CHR14-b, a-CH¿2?-CH2-CHR?13-NR12¿-b, a-NR?12-CHR13-CH¿2-CH2-b, a-CH2-CH2-NR12-CH2-CH2-b, a-CH2-CH2-CH2-NR12-CH2-b, a-CH2-NR12-CH2-CH2-CH2-b, a-CH2-CH2-CH2-CH2-NR12-b, a-NR12-CH2-CH2-CH2-CH2-b, wherein R12 is hydrogen, CH¿2?CH2OH, or alkyl, and R?13 and R14¿ are each independently hydrogen, CN, CONH¿2?, CH2NH2, CH2OH, alkyl, arylalkyl, alkenyl or CO2R?15¿, wherein R15 is hydrogen or alkyl. The compounds are useful in the treatment of disorders of mammals, responsive to the blockade of glutamic and aspartic acid receptors. Processes for preparing the compounds and novel intermediate useful in the processes are also included.
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公开(公告)号：EP0664807A1
公开(公告)日：1995-08-02
申请号：EP93922849.0
申请日：1993-10-08
CPC分类号： C07D471/04 , C07D217/04 , C07D487/04 , C07F9/6561
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3.发明公开PHARMACEUTICAL PREPARATION CONTAINING AN URICOSURIC AND AN EXCITATORY AMINO ACID ANTAGONIST 失效药物组合，制备将URICOSURICHES剂对兴奋性氨基酸拮抗剂包含的内容。
公开(公告)号：EP0603301A1
公开(公告)日：1994-06-29
申请号：EP92919882.0
申请日：1992-09-02
发明人： BIGGE, Christopher, Franklin , JOHNSON, Graham , TAYLOR, Charles, Price, Jr. , WELTY, Devin, Franklin
CPC分类号： A61K31/675 , A61K31/18 , A61K31/47 , A61K31/495 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.
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