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公开(公告)号：EP0830338B1
公开(公告)日：2001-12-12
申请号：EP96914618.2
申请日：1996-05-13
发明人： GROTE, Todd, Michel , HUCKABEE, Brian, Keith , MULHERN, Thomas , SOBIERAY, Denis, Martin , TITUS, Robert, Daniel
IPC分类号： C07C229/08 , C07C255/19 , C07C255/22 , C07C227/04
CPC分类号： C07C227/34 , C07C227/10 , C07C229/08 , C07C255/19 , C07C255/22
摘要： A method of making (±)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (±)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (±)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (±)-3-(aminomethyl)-5-methylhexanoic acid.
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公开(公告)号：EP0830338A1
公开(公告)日：1998-03-25
申请号：EP96914618.0
申请日：1996-05-13
发明人： GROTE, Todd, Michel , HUCKABEE, Brian, Keith , MULHERN, Thomas , SOBIERAY, Denis, Martin , TITUS, Robert, Daniel
CPC分类号： C07C227/34 , C07C227/10 , C07C229/08 , C07C255/19 , C07C255/22
摘要： A method of making (±)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydrolyzing the (V) with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (±)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (±)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (±)-3-(aminomethyl)-5-methylhexanoic acid.
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