公开(公告)号：EP1490015B1

公开(公告)日：2009-09-23

申请号：EP03764294.9

申请日：2003-03-13

申请人： WAYNE STATE UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： ZEMLICKA, Jiri ,  DRACH, John, C. ,  CHEN, Xinchao

IPC分类号： A61K6/00 ,  C07D473/18 ,  C07D473/16 ,  C07D473/24 ,  A61K31/522 ,  A61P31/18 ,  A61P31/22 ,  C07F9/6506

CPC分类号： C07D473/00 ,  C07F9/65616

摘要： Compounds which are active against viruses have the Formulas (I) and (II), wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; Rl is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.