公开(公告)号：EP1534718A1

公开(公告)日：2005-06-01

申请号：EP03757381.3

申请日：2003-06-06

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： RAINES, Ronald, T. ,  KIESSLING, Laura, L. ,  NILSSON, Bradley, L. ,  HE, Yi ,  SOELLNER, Matthew, B. ,  HINKLIN, Roland, J.

IPC分类号： C07F5/02 ,  C07K2/00 ,  C07K17/00 ,  C07K14/00

CPC分类号： C07F9/5004 ,  C07F9/5045 ,  C07K1/006 ,  C07K5/06026

摘要： The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphineborane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.