专利检索 ap:("WOCKHARDT LTD" OR "JAWEED MUKARRAM SIDDIQUI MOHAM" OR "MERWADE ARAVIND YEKANATHSA" OR "SINGH KUMAR KAMLESH LAXMI" OR "SOLANKI PAWAN VRAJLAL") AND inv:"SINGH KUMAR KAMLESH LAXMI" 第 1 页

1.

发明公开
PROCESS FOR THE PREPARING ZIPRASIDONE MONOHYDROCHLORIDE HYDRATE 审中-公开
标题翻译：用于生产ZIPRASIDONMONOHYDROCHLORID水合物

公开(公告)号：EP1687300A4

公开(公告)日：2007-08-01

申请号：EP03778599

申请日：2003-11-28

申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , MERWADE ARAVIND YEKANATHSA , SINGH KUMAR KAMLESH LAXMI , SOLANKI PAWAN VRAJLAL

发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , MERWADE ARAVIND YEKANATHSA , SINGH KUMAR KAMLESH LAXMI , SOLANKI PAWAN VRAJLAL

IPC分类号： C07D417/04 , C07D417/12

CPC分类号： C07D417/12

摘要： The present invention describes a process for preparing 5-(2-(4-1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one (Ziprasidone) monohydrochloride hydrate or a pharmaceutically acceptable acid addition salt thereof, which is well known agent for treating various disorders including schizophrenia, migraine pain and anxiety. The manufacturing process of Ziprasidone comprises the reaction of hydrochloride salt of 1,2-benzisothiazole-3-piprazinyl with 2-Chloroethyl-6-chlorooxindole in aqueous sodium carbonate solution. Its hydrochloride salt is prepared in aqueous methanol using hydrogen chloride.