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    NOVEL POLYMER AND METHOD OF MEASURING CHOLESTEROL THEREWITH
    1.
    发明公开
    NOVEL POLYMER AND METHOD OF MEASURING CHOLESTEROL THEREWITH 有权
    消除聚合物VERFAHREN ZUR MESSUNG VON CHOLESTERIN DAMIT

    公开(公告)号：EP1903069A1

    公开(公告)日：2008-03-26

    申请号：EP06729024.7

    申请日：2006-03-14

    申请人： Wako Pure Chemical Industries, Ltd.

    发明人： ITAI, Tomokazu ,  MORI, Kiyoko ,  YAGURA, Yo ,  KOYAMA, Isao ,  YAMAMOTO, Naoyuki

    IPC分类号： C08G81/00 ,  C08F4/04 ,  C08F293/00 ,  C12Q1/26 ,  C12Q1/44 ,  C12Q1/60 ,  G01N33/68 ,  G01N33/92

    CPC分类号： G01N33/92 ,  C08F210/00 ,  C08F293/00 ,  C08F293/005 ,  G01N2800/044

    摘要： It is an object of the present invention to provide the method for determining cholesterol in lipoprotein and reagent for determining cholesterol comprising the polymer, and the present invention relates to the reagent for determining cholesterol in lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein(LDL) and very low-density lipoprotein(VLDL) and the determination method using the polymer comprising the following units as constituents:
    (iv) a polyethylene glycol segment represented by the general formula [1]:

            (CH 2 CH 2 O)k-     [1]

    (wherein, k represents an integer of 10 to 250);
    (v) a monomer unit represented by the general formula [2]:

    (wherein R 1 represents a hydrogen atom or C 1 -C 3 alkyl group); and
    (vi) a monomer unit represented by the general formula [3]:

    [wherein, R 2 represents a hydrogen atom or C 1 -C 3 alkyl group, and R 3 represents a group represented by the general formula [4]:

            -COOR 4      [4]

    (wherein, R 4 represents an alkyl group, a haloalkyl group or a bornyl group), an alkyl group, an alkoxy group, an aralkyl group or an alkylcarbamoyl group; particularly, in the direct measurement of cholesterols such as HDL, LDL and VLDL contained in the sample, the reagent for determining cholesterol in the presence of said polymer, and the method for determining the concentration of cholesterol in a specific lipoprotein using said reagent for determining cholesterol, and a novel polymer.

    摘要翻译： 本发明的目的是提供用于测定脂蛋白中的胆固醇的方法和用于测定包含该聚合物的胆固醇的试剂，本发明涉及用于测定脂蛋白中的胆固醇的试剂，例如高密度脂蛋白（HDL），低密度脂蛋白 密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）以及使用包含以下单位的聚合物作为成分的测定方法：（iv）由通式[1]表示的聚乙二醇片段：€ƒ€€ ƒ€ƒ€ƒ€ƒ€ƒ（CH 2 CH 2 O）k-€ƒ€ƒ€ƒƒ[1]（其中，k表示10到250的整数）; （v）由通式[2]表示的单体单元：（其中R 1表示氢原子或C 1 -C 3烷基）; 和（vi）由通式[3]表示的单体单元：[其中，R 2表示氢原子或C 1〜C 3烷基，R 3表示由通式[4]表示的基团： ƒ€ƒ€ƒ€ƒ€€ƒ€ƒ-COOR 4€ƒ€ƒ€ƒ€ƒ[4]（其中，R 4表示烷基，卤代烷基或冰基）， 烷基，烷氧基，芳烷基或烷基氨基甲酰基; 特别是直接测定样品中所含的HDL，LDL，VLDL等胆固醇的方法，在所述聚合物存在下，测定胆固醇的试剂，以及使用所述试剂测定特定脂蛋白中的胆固醇浓度的方法 胆固醇和新型聚合物。