公开(公告)号：EP3235876A1

公开(公告)日：2017-10-25

申请号：EP15870088.0

申请日：2015-12-18

申请人： Wako Pure Chemical Industries, Ltd.

发明人： SUZUKI Katsufumi ,  TSURUMI Yoshihisa ,  KAWANO Kei ,  IMAZEKI Shigeaki ,  MURASE Tetsuji

IPC分类号： C09B11/28 ,  C07D311/78 ,  C07D311/82 ,  C07D491/16 ,  C07D493/10 ,  C08F20/30 ,  G02B5/20

CPC分类号： C07D209/88 ,  C07D491/16 ,  C07D493/10 ,  C08F20/30 ,  C09B11/24 ,  C09B69/06 ,  C09B69/103 ,  G02B5/20

摘要： Conventional quenchers do not have quenching ability enough to suppress fluorescence emission of compounds having fluorescent property. Accordingly, it is an object of the present invention to provide a quencher capable of sufficiently quenching fluorescence of the compound having fluorescent property, including a xanthene-based dye.
The present invention relates to a quencher, or the like, comprising a compound represented by the following general formula (1):

[wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An - represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer;
and the following structure (1-10) in the general formula (1) is an asymmetric structure;

(wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).].

摘要翻译： 常规猝灭剂不具有足以抑制具有荧光特性的化合物的荧光发射的猝灭能力。 因此，本发明的目的是提供能够充分猝灭包括x吨系染料在内的具有荧光性的化合物的荧光的猝灭剂。 本发明涉及包含由下述通式（1）表示的化合物的猝灭剂等：[其中R 5各自独立地表示卤素原子，烷基，烷氧基，烷硫基，氨基 具有或不具有取代基的取代基，羟基，芳基，芳氧基或芳基烷基; R6表示具有聚合性不饱和基团，羟基等的基团; Y1表示氧原子等; An-代表阴离子; Ar1表示特定的环结构; *和**代表结合位置; Ar 2表示苯环，萘环或蒽环; n1表示特定的整数; 以及通式（1）中的以下结构（1-10）为不对称结构; （其中R5，Y1，Ar1，Ar2，n1，*和**与上述相同。）。]。