公开(公告)号：EP2335048A1

公开(公告)日：2011-06-22

申请号：EP09748821.7

申请日：2009-10-01

申请人： Wallac OY

发明人： VÄISÄNEN, Ville ,  KARVINEN, Jarkko ,  HURSKAINEN, Pertti ,  TUOMOLA, Elina

IPC分类号： G01N21/15 ,  G01N21/64 ,  G01N21/90 ,  B01L3/00 ,  C12Q1/48 ,  G01N1/28 ,  G01N33/487

CPC分类号： G01N21/6428 ,  G01N1/286 ,  G01N1/38 ,  G01N21/15 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/94 ,  G01N35/00663 ,  G01N2021/6432 ,  G01N2021/646

摘要： The invention relates to a method and apparatus for detecting undesired measurement conditions in a sample container. The method comprises measuring a fluorescent property of the sample container comprising a sample substrate with impregnated blood sample and incubation buffer to which the blood sample is to be eluted, and determining, based on temporal and/or spectral characteristics of the fluorescent property, whether the fluorescent property is characteristic to a sample container comprising a sample substrate and incubation buffer under said undesired measurement conditions or to a sample container suitable for optical measurement of analyte contained in the sample. Thus undesired measurement condition can be a floating sample substrate or a foreign body in the sample container. By means of the invention, reliability of neonatal screening, for example, can be increased.

公开(公告)号：EP2335048B1

公开(公告)日：2015-12-23

申请号：EP09748821.7

申请日：2009-10-01

申请人： Wallac OY

发明人： VÄISÄNEN, Ville ,  KARVINEN, Jarkko ,  HURSKAINEN, Pertti ,  TUOMOLA, Elina

IPC分类号： G01N21/15 ,  G01N21/64 ,  G01N21/94 ,  G01N1/28 ,  G01N35/00

CPC分类号： G01N21/6428 ,  G01N1/286 ,  G01N1/38 ,  G01N21/15 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/94 ,  G01N35/00663 ,  G01N2021/6432 ,  G01N2021/646

摘要： The invention relates to a method and apparatus for detecting undesired measurement conditions in a sample container. The method comprises measuring a fluorescent property of the sample container comprising a sample substrate with impregnated blood sample and incubation buffer to which the blood sample is to be eluted, and determining, based on temporal and/or spectral characteristics of the fluorescent property, whether the fluorescent property is characteristic to a sample container comprising a sample substrate and incubation buffer under said undesired measurement conditions or to a sample container suitable for optical measurement of analyte contained in the sample. Thus undesired measurement condition can be a floating sample substrate or a foreign body in the sample container. By means of the invention, reliability of neonatal screening, for example, can be increased.

摘要翻译： 本发明涉及一种用于检测样品容器中不期望的测量条件的方法和装置。 该方法包括测量样品容器的荧光性质，其包括具有浸渍血液样品的样品底物和待洗脱的血液样品的孵育缓冲液，以及基于荧光性质的时间和/或光谱特性来确定 荧光性质是在所述不期望的测量条件下包含样品底物和孵育缓冲液的样品容器的特征，或适用于光学测量样品中所含分析物的样品容器。 因此，不期望的测量条件可以是样品容器中的浮动样品基底或异物。 通过本发明，可以增加例如新生儿筛查的可靠性。