公开(公告)号：EP1192125B1

公开(公告)日：2008-12-31

申请号：EP00938022.1

申请日：2000-05-31

申请人： Warner-Lambert Company LLC

发明人： BELLIOTTI, Thomas, Richard ,  BRYANS, Justin, Stephen ,  EKHATO, Ihoezo, Victor ,  OSUMA, Augustine, Tobi ,  SCHELKUN, Robert, Michael ,  THORPE, Andrew, John ,  WISE, Lawrence, David ,  WUSTROW, David, Juergen ,  YUEN, Po-Wai ,  SCHWARZ, Jacob,Bradley

IPC分类号： C07C229/08 ,  A61K31/197 ,  C07C229/30 ,  C07C229/22 ,  C07C229/34 ,  C07C229/32 ,  C07C229/20 ,  A61P25/00 ,  A61P1/00

CPC分类号： C07C229/34 ,  C07B2200/07 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C229/30 ,  C07C229/32 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

公开(公告)号：EP1192125B9

公开(公告)日：2009-09-16

申请号：EP00938022.1

申请日：2000-05-31

申请人： Warner-Lambert Company LLC

发明人： BELLIOTTI, Thomas, Richard ,  BRYANS, Justin, Stephen ,  EKHATO, Ihoezo, Victor ,  OSUMA, Augustine, Tobi ,  SCHELKUN, Robert, Michael ,  THORPE, Andrew, John ,  WISE, Lawrence, David ,  WUSTROW, David, Juergen ,  YUEN, Po-Wai ,  SCHWARZ, Jacob,Bradley

IPC分类号： C07C229/08 ,  A61K31/197 ,  C07C229/30 ,  C07C229/22 ,  C07C229/34 ,  C07C229/32 ,  C07C229/20 ,  A61P25/00 ,  A61P1/00

CPC分类号： C07C229/34 ,  C07B2200/07 ,  C07C229/08 ,  C07C229/20 ,  C07C229/22 ,  C07C229/30 ,  C07C229/32 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

摘要翻译： 本发明是一系列式（I）的新颖的单取代和二取代的3-丙基γ-氨基丁酸。 这些化合物可用作治疗癫痫，微弱发作，运动功能减退，颅内疾病，神经变性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，关节炎，睡眠障碍，IBS和胃损伤的治疗剂。 制备化合物和有用的中间体的方法也是本发明的一部分。