专利检索 ap:("Warszawski Uniwersytet Medyczny" OR "Instytut Biochemii I Biofizyki Pan") AND inv:"ZAGOZDZON, Radoslaw" 第 1 页

1.

发明公开
METHOD OF DIFFERENTIATING OF A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY, METHOD OF MONITORING A RESPONSE TO TREATMENT OF A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY IN A SUBJECT AND A METHOD OF TREATMENT OF A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY 审中-公开

公开(公告)号：EP4097481A1

公开(公告)日：2022-12-07

申请号：EP20816594.4

申请日：2020-11-10

申请人： Warszawski Uniwersytet Medyczny , Instytut Biochemii I Biofizyki Pan

发明人： MUCHA, Krzysztof , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , PACZEK, Leszek , MOSZCZUK, Barbara , KRATA, Natalia , CYSEWSKI, Dominik , DOMANSKI, Dominik , DADLEZ, Michal , BURDUKIEWICZ, Michal

IPC分类号： G01N33/68

2.

发明公开
METHOD OF SCREENING FOR A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY, METHOD OF MONITORING A RESPONSE TO TREATMENT OF A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY IN A SUBJECT AND A METHOD OF TREATMENT OF A CHRONIC KIDNEY DISEASE OR GLOMERULOPATHY 审中-公开

公开(公告)号：EP4097480A1

公开(公告)日：2022-12-07

申请号：EP20816593.6

申请日：2020-11-10

申请人： Warszawski Uniwersytet Medyczny , Instytut Biochemii I Biofizyki Pan

发明人： MUCHA, Krzysztof , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , PACZEK, Leszek , MOSZCZUK, Barbara , KRATA, Natalia , CYSEWSKI, Dominik , DOMANSKI, Dominik , DADLEZ, Michal , BURDUKIEWICZ, Michal

IPC分类号： G01N33/68

3.

发明公开
METHODS FOR DIAGNOSIS, DIFFERENTIATION AND MONITORING USING URINE PROTEINS AS MARKERS IN IGA NEPHROPATHY 审中-公开

公开(公告)号：EP3469372A1

公开(公告)日：2019-04-17

申请号：EP17736762.0

申请日：2017-06-12

申请人： Warszawski Uniwersytet Medyczny , Instytut Biochemii I Biofizyki Polskiej Akademii Nauk

发明人： MUCHA, Krzysztof , PACZEK, Leszek , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , DADLEZ, Michal , BAKUN, Magdalena , PIWOWARSKI, Jan , PILZYS, Tomas , MARCINKOWSKI, Michal , GARBICZ, Damian , GRZESIUK, Elzbieta , FLORCZAK, Michal

IPC分类号： G01N33/68

4.

发明授权
SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES 有权

公开(公告)号：EP3181118B1

公开(公告)日：2019-02-13

申请号：EP15461585.0

申请日：2015-12-14

申请人： Warszawski Uniwersytet Medyczny

发明人： ZAGOZDZON, Radoslaw , FIRCZUK, Malgorzata , GRACZYK-JARZYNKA, Agnieszka , TRZECIECKA, Anna , BAJOR, Malgorzata

IPC分类号： A61K9/00 , A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61P35/02

5.

发明公开
USE OF SERUM 2-CYSTEINE PEROXIREDOXINS (2-CYS-PRDX) AS BIOMARKERS OF CHRONIC KIDNEY DISEASES (CKD) SUCH AS LUPUS NEPHRITIS (LN), IGA NEPHROPATHY (IGAN) AND AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USEFUL FOR DIAGNOSING, MONITORING, AND PROGNOSING IN THESE DISEASES AND METHOD OF DIFFERENTIATION OF THESE DISEASES 审中-公开

公开(公告)号：EP3358355A1

公开(公告)日：2018-08-08

申请号：EP17461508.8

申请日：2017-02-04

申请人： Warszawski Uniwersytet Medyczny

发明人： MUCHA, Krzysztof , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , PACZEK, Leszek , KRATA, Natalia , GALA, Kamila

IPC分类号： G01N33/68 , G01N33/564

CPC分类号： G01N33/6893 , G01N33/564 , G01N2333/908 , G01N2800/347

摘要： The resent invention relates to the use of at least one of 2-Cys-PRDXs selected from a group consisting of PRDX1, PRDX2, PRDX3, PRDX4 and PRDX5 as a biomarker to diagnose, differentiate and/or assess the risk of chronic kidney disease (CDK). Present invention also relates to the method of diagnosis and the method of determining an increased risk of chronic kidney disease (CKD). Present invention also provides a kit suitable for diagnosis and differentiation of chronic kidney disease (CKD) selected from the group comprising lupus nephritis (LN), IgA nephropathy (IgAN) and autosomal-dominant polycystic kidney disease (ADPKD) in a subject.

6.

发明公开
SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES 审中-公开
标题翻译： TXNR抑制剂与抗坏血酸的协同处理治疗B细胞恶性肿瘤

公开(公告)号：EP3181118A1

公开(公告)日：2017-06-21

申请号：EP15461585.0

申请日：2015-12-14

申请人： Warszawski Uniwersytet Medyczny

发明人： ZAGOZDZON, Radoslaw , FIRCZUK, Malgorzata

IPC分类号： A61K9/00 , A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61P35/02

CPC分类号： A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61K2300/00

摘要： The present invention relates to a prooxidant synergistic combination to treat B-cell malignancies, such as B cell lymphomas, which comprises a thioredoxin reductase inhibitor, selected from a group comprising auranofin and SK053, and L- or D-ascorbate. The combination of the invention exerts synergistic cytotoxic effects towards malignant, but not normal B cells.

摘要翻译： 本发明涉及用于治疗B细胞恶性肿瘤（例如B细胞淋巴瘤）的促氧化剂协同组合，其包含选自包含金诺芬和SK053的组的硫氧还蛋白还原酶抑制剂和L-或D-抗坏血酸盐。本发明的组合对恶性而非正常的B细胞发挥协同的细胞毒性作用。