公开(公告)号：EP0993483A1

公开(公告)日：2000-04-19

申请号：EP98932368.8

申请日：1998-07-03

申请人： West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited

发明人： DAVIS, Stanley Stewart ,  LIN, Wu ,  BIGNOTTI, Fabio ,  FERRUTI, Paolo

IPC分类号： C08G81/00 ,  C08B37/08 ,  A61K31/735 ,  A61K9/127 ,  A61K9/50 ,  A61K9/16

CPC分类号： A61K9/5161 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/1652 ,  A61K47/61 ,  C08B37/003 ,  C08G81/00

摘要： PEG-chitosan conjugates comprising chitosan and polyethylene glycol moieties or derivatives thereof which are bonded together and their use in medicine is described. In one embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together via the amino function on the chitosan by the use of an activated chitosan species. In another embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together, the chitosan portion of the conjugate having a molecular weight in the range of from 10 kilodalton to 1000 kilodalton.