专利检索 ap:("Westin, Gunnar" OR "Björklund, Peyman" OR "Akerstrom, Goran") AND inv:"Björklund, Peyman" 第 1 页

1.

发明公开
MUTANT LRP5/6 WNT-SIGNALING RECEPTORS IN CANCER DIAGNOSIS, PROGNOSIS AND TREATMENT 审中-公开
标题翻译：突变体LRP5 / 6 WNT信号受体在癌症诊断，预测工程

公开(公告)号：EP1692167A2

公开(公告)日：2006-08-23

申请号：EP04816633.4

申请日：2004-11-24

申请人： Westin, Gunnar , Björklund, Peyman , Akerstrom, Goran

发明人： Westin, Gunnar , Björklund, Peyman , Akerstrom, Goran

IPC分类号： C07K14/51 , C12N15/85

CPC分类号： G01N33/574 , A01K2217/05 , C07K14/705 , G01N33/5011 , G01N33/57407 , G01N2800/046 , G01N2800/52

摘要： A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of diagnosing, prognosing and treating LRP5related diseases, specifically hyperparathyroidism and parathyroid tumors, and kits suitable for rapid on-site testing. Finally, methods of screening for agents capable of modulating the mutant LRP5 or LRP6 receptor proteins and pharmaceutical compositions comprising the selected agents.