公开(公告)号：EP3609538A1

公开(公告)日：2020-02-19

申请号：EP18783697.8

申请日：2018-04-11

Applicant: William Marsh Rice University

Inventor： NICOLAOU, Kyriacos C. ,  RHOADES, Derek ,  WANG, Yanping

IPC: A61K39/395 ,  A61K39/40

公开(公告)号：EP3468976A2

公开(公告)日：2019-04-17

申请号：EP17811026.8

申请日：2017-06-08

Applicant: William Marsh Rice University

Inventor： NICOLAOU, Kyriacos, C. ,  RHOADES, Derek ,  KUMAR, Soundarapandian, M. ,  PATTANAYAK, Manas, R. ,  LAMANI, Manjunath

IPC: C07D491/052 ,  C07D498/18 ,  C12P17/18

公开(公告)号：EP3371176A1

公开(公告)日：2018-09-12

申请号：EP16856299.9

申请日：2016-10-14

Applicant: William Marsh Rice University

Inventor： NICOLAOU, Kyriacos, C. ,  RHOADES, Derek ,  WANG, Yanping ,  TOTOKOTSOPOULOS, Sotirios

IPC: C07D407/06 ,  C07D405/06 ,  A61K31/425

CPC classification number: C07D407/06 ,  A61K31/4155 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4427 ,  A61K39/395 ,  A61K45/06 ,  C07D405/06 ,  C07D491/08 ,  C07D493/08 ,  A61K2300/00

Abstract: In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.