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23 条记录 (耗时 0.018 秒)

    2-ALKYLIDENE-18,19-DINOR-VITAMIN D COMPOUNDS
    3.
    发明授权
    2-ALKYLIDENE-18,19-DINOR-VITAMIN D COMPOUNDS 有权
    2- ALKYLIDEN 18.19恐龙维生素-D-VERBINDUNGEN

    公开(公告)号：EP1735277B1

    公开(公告)日：2011-11-23

    申请号：EP05722702.7

    申请日：2005-02-04

    申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

    发明人： DELUCA, Hector, F. ,  BARYCKI, Rafal ,  GRZYWACZ, Pawel, K. ,  PLUM, Lori, A. ,  SICINSKI, Rafal, R.

    IPC分类号： C07C401/00 ,  A61K31/593 ,  A61P3/14 ,  A61P19/10 ,  A61P17/06 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06

    CPC分类号： C07C401/00 ,  Y02P20/55 ,  Y10S514/825

    摘要： 2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by low bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. These compounds also increase both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements.

    (20R)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS
    8.
    发明公开
    (20R)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS 有权
    （20R）-23.23二氟-2-亚甲基-19-去甲维生素BISHOMOPREGNACALCIFEROL D类似物

    公开(公告)号：EP2237837A1

    公开(公告)日：2010-10-13

    申请号：EP08869002.9

    申请日：2008-12-24

    申请人： Wisconsin Alumni Research Foundation

    发明人： DELUCA, Hector, F. ,  CLAGETT-DAME, Margaret ,  PLUM, Lori, A. ,  BARYCKI, Rafal

    IPC分类号： A61P17/00 ,  A61K31/593 ,  C07C401/00

    CPC分类号： C07D401/00

    摘要： This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20R)-23,23-difluoro-lα-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.