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1.发明公开DETECTION OF RATE CHANGES IN SYSTEMATIC OSCILLATIONS OF METABOLIC PATHWAYS BY MONITORING ISOTOPE RATIOS 审中-公开检出率变动表监测同位素比值的的代谢路径下的系统变化的
公开(公告)号：EP2839277A2
公开(公告)日：2015-02-25
申请号：EP13701877.6
申请日：2013-01-07
IPC分类号： G01N33/497 , A61B5/00
CPC分类号： G01N33/497 , A61B5/082 , A61B5/0836 , A61B5/412 , A61B5/4842 , A61B5/4845 , G06F19/00
摘要： The methods described herein are based on the observation that oscillations in breath isotope ratio data can be used for the purpose of identifying an "unhealthy" state in an organism such as a human. Described herein are methods of determining the state of health of an individual, such as the transition from healthy to infected, by identifying changes in oscillation modes in breath isotope ratio data. Changes in the frequency and/or amplitude of the oscillation modes are correlated with the heath of the individual. The methods can advantageously be used to provide information about the health of an individual in shorter periods of time than previous methods.
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2.发明公开
公开(公告)号：EP2081963A2
公开(公告)日：2009-07-29
申请号：EP07871216.3
申请日：2007-10-23
发明人： COOK, Mark , PETKOVICH, Martin , HELLESTAD, Erica
IPC分类号： C07K16/44 , A61K39/395 , A61P3/12 , A61P13/12
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/11 , C07K2317/23 , C07K2317/76
摘要： It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at risk of developing hyperphosphatemia. The method includes the step of administering orally to the subject an anti-phytic acid (C6H6[OPO(OH)2]O) antibody or an anti- phytate antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
摘要翻译： 这里公开了一种在人或非人动物受试者中减少磷酸盐吸收的方法，其中所述受试者消耗含有植酸或植酸盐的饮食，并且具有或具有发生高磷酸血症的风险。 该方法包括以有效降低或维持受试者血清磷酸盐浓度的量向受试者口服抗肌醇六磷酸（C 6 H 6 [OPO（OH）2] o）抗体或抗肌醇六磷酸酯抗体的步骤。
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公开(公告)号：EP2076286A2
公开(公告)日：2009-07-08
申请号：EP07844538.4
申请日：2007-10-23
IPC分类号： A61K39/395 , A61P13/12 , C07K16/02
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/542 , C07K2317/34 , C07K2317/76
摘要： A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administering orally to the subject an anti-intestinal sodium phosphate cotransporter type 2B (Npt2B) antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
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4.发明授权METHODS OF REDUCING PHOSPHATE ABSORPTION USING AN ANTI-NPT2B ANTIBODY 有权一种用于减少磷素营养的吸收利用一抗 - 抗体NPT2B
公开(公告)号：EP2076286B1
公开(公告)日：2016-03-09
申请号：EP07844538.4
申请日：2007-10-23
IPC分类号： A61K39/395 , A61P13/12 , C07K16/02
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/542 , C07K2317/34 , C07K2317/76
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公开(公告)号：EP2076543A2
公开(公告)日：2009-07-08
申请号：EP07844535.0
申请日：2007-10-23
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/11 , C07K2317/23 , C07K2317/76
摘要： It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at risk of developing hyperphosphatemia. The method includes the step of administering orally to the subject an anti-intestinal alkaline phosphatase antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
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公开(公告)号：EP2076543B1
公开(公告)日：2016-01-27
申请号：EP07844535.0
申请日：2007-10-23
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/11 , C07K2317/23 , C07K2317/76
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公开(公告)号：EP1227818A2
公开(公告)日：2002-08-07
申请号：EP00976795.5
申请日：2000-11-01
发明人： ATTIE, Alan, D. , COOK, Mark , GRAY-KELLER, Mark, P. , HAYDEN, Michael, R. , PIMSTONE, Simon , BROOKS-WILSON, Angie
IPC分类号： A61K31/64
CPC分类号： C12Q1/6883 , A61K31/64 , A61K49/0008 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044
摘要： Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
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