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1.发明授权
公开(公告)号：EP3058094B1
公开(公告)日：2018-01-17
申请号：EP14810038.1
申请日：2014-10-15
发明人： PULA, Bartosz , OLBROMSKI, Mateusz , AMBICKA, Aleksandra , GOMULKIEWICZ, Agnieszka , RYS, Janusz , PODHORSKA-OKOLÓW, Marzena , SIEW, Hwa, Ong , DZIEGIEL, Piotr
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to a method for detection of decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines in breast cancer patients, according to which the evaluation of PIP gene expression is performed with the use of real-time PCR method on the isolated total RNA in the sample of tissue material taken from patient from primary tumour of ductal breast cancer, wherein the statistically significant lower expression of PIP mRNA indicates decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines. The invention provides a prediction test, which enables rapid classification of patients in terms of their responsiveness for adjuvant chemotherapy and thus the undertaking of appropriate therapeutic intervention.
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2.发明授权A METHOD OF DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID, A KIT TO EMBODY THE METHOD AND THE USE OF METALLOTHIONEIN (MT) FOR DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID 有权METHOD FOR分化致癌变化在甲状腺癌中，KIT FOR FOR甲状腺癌基因变化的DISTINCTION实现该方法金属硫的使用（MT）
公开(公告)号：EP2656078B1
公开(公告)日：2016-10-26
申请号：EP11819026.3
申请日：2011-12-21
发明人： DZIEGIEL, Piotr , PODHORSKA-OKOLÓW, Marzena , KRÓLICKA, Anna , KOBIERZYCKI, Christopher , PULA, Bartosz , PIOTROWSKA, Aleksandra
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57407 , G01N2333/825
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3.发明公开A METHOD OF DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID, A KIT TO EMBODY THE METHOD AND THE USE OF METALLOTHIONEIN (MT) FOR DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID 有权METHOD FOR分化致癌变化在甲状腺癌中，KIT FOR FOR甲状腺癌基因变化的DISTINCTION实现该方法金属硫的使用（MT）
公开(公告)号：EP2656078A1
公开(公告)日：2013-10-30
申请号：EP11819026.3
申请日：2011-12-21
发明人： DZIEGIEL, Piotr , PODHORSKA-OKOLÓW, Marzena , KRÓLICKA, Anna , KOBIERZYCKI, Christopher , PULA, Bartosz , PIOTROWSKA, Aleksandra
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/6893 , G01N33/57407 , G01N2333/825
摘要： A method of differentiating oncogenic changes of the thyroid encompassing follicular adenoma and follicular cancer, characterised in that in a sample of oncogenic tissue from a patient the expression of the metallothionein (MT) potein is evaluated using immunochistochemical methods using monoclonal anti-MT antibodies, the degree of intensity of the expression of metallothionein is evaluated under a light microscope using the semiquantitative IRS method according to Remmele, wherein if the degree of intensity of the expression of metallothionein is equal to or greater than 8 on the semiquantitative IRS scale then the presence of follicular cancer is indicated.
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