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    CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME
    2.
    发明公开
    CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARB-ONITRILE AND METHODS OF PREPARING THE SAME 有权
    4 - [（2,4-二氯-5-甲氧基苯基）氨基] -6-甲氧基-7- [3-（4-甲基-1-哌嗪基）丙氧基] -3-喹啉羧酸乙酯的结晶形式及制备方法 一样

    公开(公告)号：EP1902029A1

    公开(公告)日：2008-03-26

    申请号：EP06774184.3

    申请日：2006-06-28

    申请人： Wyeth

    发明人： TESCONI, Marc, Sadler ,  FEIGELSON, Gregg ,  STRONG, Henry ,  WEN, Hong

    IPC分类号： C07D215/54 ,  A61K31/4709

    CPC分类号： C07D215/54

    摘要： This invention is directed to a crystalline 4-[(2,4-dichloro-5- methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-l-piperazinyl)propoxy]-3- quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 20 angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109ºC to about 115ºC.

    摘要翻译： 本发明涉及结晶的4 - [（2,4-二氯-5-甲氧基苯基）氨基] -6-甲氧基-7- [3-（4-甲基-1-哌嗪基）丙氧基] -3-喹啉甲腈一水合物， 其中显着峰的20个角度（°）在约9.19,11.48,14.32,19.16,19.45,20.46,21.29,22.33,23.96,24.95,25.29,25.84,26.55,27.61和29.51处的x-射线衍射图， 和约109℃至约115℃的转变温度。