公开(公告)号：EP1874763A2

公开(公告)日：2008-01-09

申请号：EP06751521.3

申请日：2006-04-26

申请人： Wyeth

发明人： TESCONI, Marc, Sadler ,  KU, Mannching, Sherry ,  XU, Yan

IPC分类号： C07D413/04 ,  A61K31/536 ,  A61P5/24 ,  A61P15/00

CPC分类号： C07D413/04 ,  C07D265/18 ,  C07B2200/13

摘要： Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Foπn II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.

摘要翻译： Tanaproget多晶型II，制备tanaproget多晶型II的方法，包括tanaproget多晶型物II的药物组合物，II型微粉化的tanaproget多晶型物，以及将II型转化成tanaproget I型的方法。 还提供了避孕，激素替代疗法，刺激食物摄取和治疗或预防子宫肌瘤，良性前列腺肥大，良性和恶性肿瘤疾病，功能失调性出血，子宫平滑肌瘤，子宫内膜异位症，多囊卵巢综合征或癌和腺癌的方法， 将多晶型II给药至哺乳动物受试者。