公开(公告)号：EP1341779B1

公开(公告)日：2006-06-21

申请号：EP01993277.1

申请日：2001-12-11

申请人： Wyeth ,  ARQULE, INC.

发明人： KREFT, Anthony Frank ,  COLE, Derek Cecil ,  WOLLER, Kevin Roger ,  STOCK, Joseph Raymond ,  DIAMANITIS, George ,  KURBRAK, Dennis Michael ,  KUTTERER, Kristina Martha ,  MOORE, William Jay ,  CASEBIER, David Scott

IPC分类号： C07D333/34 ,  C07D409/12 ,  C07D307/64 ,  A61K31/381 ,  A61K31/4535 ,  A61K31/341 ,  A61P25/28

CPC分类号： C07D409/12 ,  C07D307/64 ,  C07D333/34

摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.

公开(公告)号：EP1341779A2

公开(公告)日：2003-09-10

申请号：EP01993277.1

申请日：2001-12-11

申请人： Wyeth ,  ARQULE, INC.

发明人： KREFT, Anthony Frank ,  COLE, Derek Cecil ,  WOLLER, Kevin Roger ,  STOCK, Joseph Raymond ,  DIAMANITIS, George ,  KURBRAK, Dennis Michael ,  KUTTERER, Kristina Martha ,  MOORE, William Jay ,  CASEBIER, David Scott

IPC分类号： C07D333/34 ,  C07D409/12 ,  C07D307/64 ,  A61K31/381 ,  A61K31/4535 ,  A61K31/341 ,  A61P25/28

CPC分类号： C07D409/12 ,  C07D307/64 ,  C07D333/34

摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.