-
1.发明授权SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS 失效取代喹唑啉衍生物及其作为酪氨酸激酶抑制剂
公开(公告)号：EP1000039B1
公开(公告)日：2004-06-09
申请号：EP98937275.0
申请日：1998-07-29
IPC分类号： C07D239/94 , C07D405/12 , A61K31/505
CPC分类号： C07D401/12 , C07D239/94
摘要： This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.
-
公开(公告)号：EP0973746B1
公开(公告)日：2003-09-24
申请号：EP98914417.5
申请日：1998-04-02
发明人： WISSNER, Allan , JOHNSON, Bernard, Dean , REICH, Marvin, Fred , FLOYD, Middleton, Brawner, Jr. , KITCHEN, Douglas, B. , TSOU, Hwei-Ru
IPC分类号： C07D215/54 , A61K31/47 , C07D401/12
CPC分类号： C07D401/12 , C07D215/54 , C07D409/12 , C07D491/04
-
公开(公告)号：EP1448531B1
公开(公告)日：2007-08-15
申请号：EP02794031.1
申请日：2002-11-26
发明人： WISSNER, Allan , TSOU, Hwei-Ru , FLOYD, Middleton, Brawner, Jr. , JOHNSON, Bernard, Dean , OVERBEEK-KLUMPERS, Elsebe, Geraldine
IPC分类号： C07D215/54 , A61K31/47 , A61P35/00
CPC分类号： C07D215/56 , C07D215/54
摘要： This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
-
公开(公告)号：EP1448531A1
公开(公告)日：2004-08-25
申请号：EP02794031.1
申请日：2002-11-26
发明人： WISSNER, Allan , TSOU, Hwei-Ru , FLOYD, Middleton, Brawner, Jr. , JOHNSON, Bernard, Dean , OVERBEEK-KLUMPERS, Elsebe, Geraldine
IPC分类号： C07D215/54 , A61K31/47 , A61P35/00
CPC分类号： C07D215/56 , C07D215/54
摘要： This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
-
-
-
搜索结果
4 条记录 (耗时 0.013 秒)
