公开(公告)号：EP2341062B1

公开(公告)日：2017-03-29

申请号：EP10182469.6

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  C12N9/40 ,  C12N9/38 ,  A61K39/39 ,  A61K47/61

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2348034B1

公开(公告)日：2016-11-02

申请号：EP10182364.9

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  C12N9/38 ,  A61K39/39 ,  A61K47/48 ,  C12N9/40

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2371838B1

公开(公告)日：2015-12-16

申请号：EP10182611.3

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟ORF2086蛋白，交叉反应性的免疫原性蛋白，其可以从nesserial菌株中分离或重组制备，包括免疫原性的部分上，生物等效物，抗体并免疫特异性地结合前述和编码每个前述的核酸序列，如 以及在免疫原性组合物中使用的相同的却是反对由脑膜炎奈瑟菌血清B.感染的有效

公开(公告)号：EP2332961B1

公开(公告)日：2016-07-27

申请号：EP10182298.9

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  A61K39/39 ,  A61K39/095 ,  C12N9/40 ,  C12N9/38 ,  A61K47/48

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2351767B1

公开(公告)日：2015-08-26

申请号：EP10182324.3

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  C12N9/38 ,  C12N9/40 ,  A61K39/095

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2366707B1

公开(公告)日：2016-09-21

申请号：EP10182399.5

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  C12N9/28 ,  C12N9/40 ,  C12N9/38 ,  A61K39/39 ,  A61K47/48 ,  G01N33/569

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟ORF2086蛋白，交叉反应性的免疫原性蛋白，其可以从nesserial菌株中分离或重组制备，包括免疫原性的部分上，生物等效物，抗体并免疫特异性地结合前述和编码每个前述的核酸序列，如 以及在免疫原性组合物中使用的相同的却是反对由脑膜炎奈瑟菌血清B.感染的有效

公开(公告)号：EP2343308B1

公开(公告)日：2015-02-18

申请号：EP10183020.6

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟氏球蛋白ORF2086蛋白质，其可以从胎心菌株分离或重组制备，包括其免疫原性部分，其生物学等同物，免疫特异性结合前述的抗体和编码上述每一种的核酸序列的交叉反应性免疫原性蛋白作为 以及在针对脑膜炎奈瑟氏球菌血清群B的感染有效的免疫原性组合物中的使用。

公开(公告)号：EP2371836B1

公开(公告)日：2016-12-14

申请号：EP10182487.8

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  C12N9/38 ,  A61K39/39 ,  A61K47/48 ,  C12N9/40

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2348036B1

公开(公告)日：2015-12-16

申请号：EP10182590.9

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： C07K1/00 ,  C07K2/00 ,  A61K39/02 ,  A61K39/095 ,  A61K38/00

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：EP2341063B1

公开(公告)日：2015-08-26

申请号：EP10182345.8

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  C12N9/38 ,  C12N9/40

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.