公开(公告)号：EP2229377A1

公开(公告)日：2010-09-22

申请号：EP08859530.1

申请日：2008-12-12

申请人： Wyeth LLC

发明人： TUMEY, Lawrence, Nathan ,  BOSCHELLI, Diane, Harris ,  BHAGIRATH, Niala ,  CHEN, Joan, Jowen ,  FLOYD, Middleton, Brawner, Jr. ,  LI, Zhong ,  NIU, Chuansheng ,  SHIM, Jaechul ,  WANG, Yan ,  WANG, Yanong, Daniel ,  WU, Biqi ,  EID, Clark, N. Jr.

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/465 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D401/12 ,  C07D401/14

摘要： Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R
1 , R
2 , R
11 , R
12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.