公开(公告)号：EP3393468A1

公开(公告)日：2018-10-31

申请号：EP16880113.2

申请日：2016-12-22

申请人： X4 Pharmaceuticals, Inc.

发明人： ARBEIT, Robert D ,  RAGAN, Paula Marie

IPC分类号： A61K31/395 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  C07D235/14 ,  C07D401/04

CPC分类号： A61K31/4709 ,  A61K9/0053 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  C07D235/14 ,  C07D401/04 ,  C07D401/12

摘要： The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.