专利检索 ap:("XenoPort, Inc.") AND inv:"FISCHER, Wolf-Nicolas" 第 1 页

1.

发明公开
COMPLEX PANTOIC ACID ESTER NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE 审中-公开
标题翻译：阿坎酸的药物前COMPLEX释放由PANTOSÄUREESTERNEOPENTYLSULFONYLESTERCYCLISIERUNG，THEREOF组合物及使用方法

公开(公告)号：EP2217564A1

公开(公告)日：2010-08-18

申请号：EP08829385.7

申请日：2008-09-05

申请人： XenoPort, Inc.

发明人： JANDELEIT, Bernd , LI, Yunxiao , GALLOP, Mark A. , ZERANGUE, Noa , VIRSIK, Peter A. , FISCHER, Wolf-Nicolas

IPC分类号： C07C309/15 , C07F9/09 , A61K31/255 , A61K31/661 , A61P25/00

CPC分类号： C07C309/15

摘要： Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate of formula (I), pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorders, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis and pain are disclosed.