公开(公告)号：EP1959948A2

公开(公告)日：2008-08-27

申请号：EP06844799.4

申请日：2006-12-04

申请人： Xenoport, Inc.

发明人： XIANG, Jia-Ning ,  DAI, Xuedong ,  ZHOU, Cindy X. ,  LI, Jianhua ,  NGUYEN, Mark Q.

IPC分类号： A61K31/24

CPC分类号： C07C229/36 ,  C07B2200/07 ,  C07B2200/13 ,  C07C229/34 ,  C07C309/04

摘要： (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.

公开(公告)号：EP1959948B1

公开(公告)日：2012-07-18

申请号：EP06844799.4

申请日：2006-12-04

申请人： XenoPort, Inc.

发明人： XIANG, Jia-Ning ,  DAI, Xuedong ,  ZHOU, Cindy X. ,  LI, Jianhua ,  NGUYEN, Mark Q.

IPC分类号： A61K31/24 ,  C07C229/36 ,  C07C309/04

CPC分类号： C07C229/36 ,  C07B2200/07 ,  C07B2200/13 ,  C07C229/34 ,  C07C309/04

摘要： (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.

公开(公告)号：EP2125702A1

公开(公告)日：2009-12-02

申请号：EP07867956.0

申请日：2007-12-20

申请人： XenoPort, Inc.

发明人： XIANG, Jia-Ning ,  ZHOU, Cindy X. ,  YAO, Fenmei ,  NGUYEN, Mark Q.

IPC分类号： C07C229/36 ,  A61K31/24 ,  A61P25/16 ,  A61P25/18 ,  A61P25/00

CPC分类号： C07C229/36

摘要： Levodopa dimethyl-substituted diester prodrugs, pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided. Formula (I)