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公开(公告)号：EP2752417B1
公开(公告)日：2017-05-31
申请号：EP14001216.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jian-Min , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
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2.发明公开
公开(公告)号：EP3241834A1
公开(公告)日：2017-11-08
申请号：EP17000910.4
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jian-Min , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义， ，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。 还公开了包含所述化合物的药物组合物以及制备和使用所述化合物的方法。
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公开(公告)号：EP2752417A1
公开(公告)日：2014-07-09
申请号：EP14001216.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jian-Min , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义， ，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。 还公开了包含所述化合物的药物组合物以及制备和使用所述化合物的方法。
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4.发明公开SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开SPIROOXINDOL-VERBINDUNGEN UND DEREN VERWENDUNGEN ALS THERAPEUTIKA
公开(公告)号：EP2942350A1
公开(公告)日：2015-11-11
申请号：EP15001588.1
申请日：2009-10-13
发明人： Chafeev, Mikhail , Fu, Jian-Min , Sun, Shaoyi , Sviridov, Serguei , Jia, Qi , Chowdhury, Sultan , Fraser, Lauren , Langille, Jonathan , Liu, Shifeng , Sun, Jianyu , Wood, Mark , Zenova, Alla , Cadieux, Jean-Jacques , Gauthier, Simon J. , Douglas, Amy Frances , Hsieh, Tom , Chakka, Nagasree , Cikojevic, Zoran
IPC分类号： C07D491/20 , C07D495/20 , C07D498/20 , C07D491/10 , C07D513/20 , A61K31/407 , A61P25/00
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映异构体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：EP2428515A1
公开(公告)日：2012-03-14
申请号：EP11009687.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jinamin , Kamboj, Rajender , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I):
wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R 1，R 2a，R 2b，R 2c，R 2d，R 3a，R 3b，R 3c和R 3d为 如本文定义的立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含该化合物的药物组合物和制备和使用该化合物的方法。
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6.发明授权
公开(公告)号：EP2428515B9
公开(公告)日：2014-09-17
申请号：EP11009687.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jianmin , Kamboj, Rajender K. , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
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7.发明授权
公开(公告)号：EP2428515B1
公开(公告)日：2014-05-07
申请号：EP11009687.2
申请日：2006-04-11
发明人： Chafeev, Mikhail , Chowdhury, Sultan , Fraser, Robert , Fu, Jianmin , Kamboj, Rajender K. , Hou, Duanjie , Liu, Shifeng , Bagherzadeh, Mehran Seid , Sviridov, Serguei , Sun, Shaoyi , Sun, Jianyu , Chakka, Nagasree , Hsieh, Tom , Raina, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
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