公开(公告)号：EP1751087B1

公开(公告)日：2012-06-27

申请号：EP05758073.0

申请日：2005-06-03

申请人： XenoPort, Inc.

发明人： XIANG, Jia-Ning ,  GALLOP, Mark, A. ,  ZHOU, Cindy, X. ,  NGUYEN, Mark ,  DAI, Xuedong ,  LI, Jianhua ,  CUNDY, Kenneth, C. ,  JUMBE, Nelson, L.

IPC分类号： C07C229/36 ,  C07C235/60 ,  C07D213/80 ,  C07D213/79 ,  A61K31/216 ,  A61K31/24 ,  A61K31/618 ,  A61K31/609 ,  A61K31/455 ,  A61K31/4409 ,  A61P25/16

CPC分类号： C07C235/60 ,  C07C229/34 ,  C07C229/36 ,  C07C235/48 ,  C07C2601/14 ,  C07D213/79 ,  C07D213/80 ,  C07D213/803

摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an integer from 2 to 4; R5 is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl; and when Q is -X--CO-, R5 is further selected from alkoxy, substituted alkoxy, cycloalkoxy, and substituted cycloalkoxy.

摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。

公开(公告)号：EP1751087A1

公开(公告)日：2007-02-14

申请号：EP05758073.0

申请日：2005-06-03

申请人： Xenoport, Inc.

发明人： XIANG, Jia-Ning ,  GALLOP, Mark, A. ,  ZHOU, Cindy, X. ,  NGUYEN, Mark ,  DAI, Xuedong ,  LI, Jianhua ,  CUNDY, Kenneth, C. ,  JUMBE, Nelson, L.

IPC分类号： C07C229/36 ,  C07C235/60 ,  C07D213/80 ,  C07D213/79 ,  A61K31/216 ,  A61K31/24 ,  A61K31/618 ,  A61K31/609 ,  A61K31/455 ,  A61K31/4409 ,  A61P25/16

CPC分类号： C07C235/60 ,  C07C229/34 ,  C07C229/36 ,  C07C235/48 ,  C07C2601/14 ,  C07D213/79 ,  C07D213/80 ,  C07D213/803

摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an integer from 2 to 4; R5 is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl; and when Q is -X--CO-, R5 is further selected from alkoxy, substituted alkoxy, cycloalkoxy, and substituted cycloalkoxy.