公开(公告)号：EP0747355A1

公开(公告)日：1996-12-11

申请号：EP95907855.1

申请日：1995-02-08

申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

发明人： TAKEUCHI, Makoto 9-14, Matsumaedai 7-chome ,  NAITO Ryo ,  MORIHIRA, Koichiro 22-5-302, Kitasenzoku 1-chome ,  HAYAKAWA, Masahiko ,  IKEDA, Ken ,  ISOMURA, Yasuo

IPC分类号： C07D211/46 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D451/04 ,  C07D453/02 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445

CPC分类号： C07D451/06 ,  C07D211/46 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D453/02

摘要： Carbamate derivatives represented by the general formula (I), salts thereof, hydrates thereof or solvates thereof
wherein each symbol has the following meaning:

A ring: a benzene ring or a pyridine ring,
B ring: a nitrogen-containing saturated hetero-ring which may have a substituent on the nitrogen atom and which may have a cross-linking,
R 1 : a phenyl group which may have a substituent, a cycloalkyl or cycloalkenyl group having 3 to 8 carbon atoms or a five- or six-membered nitrogen-containing heterocyclic group,
X: a single bond or a methylene group,
Y: a single bond, a carbonyl group, a methylene group which may be substituted with a hydroxyl group or a group represented by the formula -S(O) ℓ -, and
ℓ: an integer of 0, 1 or 2.

They have muscarinic M 3 receptor antagonism and are useful as an agent for the prevention and treatment of gastrointestinal diseases, respiratory diseases or urinary diseases.

摘要翻译： 由通式（I）表示的氨基甲酸酯衍生物，其盐，其水合物或溶剂合物其中每个符号具有以下含义：A环：苯环或吡啶环，B环：含氮饱和杂原子 其可以在氮原子上具有取代基并且可以具有交联R 1：可以具有取代基的苯基，具有3-8个碳原子的环烷基或环烯基或五或 六元含氮杂环基，X：单键或亚甲基，Y：单键，羰基，可被羟基取代的亚甲基或由式-S表示的基团（ O）1 - 和l：0,1或2的整数。它们具有毒蕈碱性M3受体拮抗作用，可用作预防和治疗胃肠道疾病，呼吸系统疾病或尿路疾病的药剂。