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5 条记录 (耗时 0.016 秒)

    N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE
    2.
    发明公开
    N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE 失效
    N-（3-吡咯烷基）BENZAMID-衍生金融

    公开(公告)号：EP0757985A1

    公开(公告)日：1997-02-12

    申请号：EP95917462.4

    申请日：1995-04-26

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： OHMORI, Junya ,  MAENO, Kyoichi ,  HIDAKA, Kazuyuki ,  NAKATO, Kazuhiro ,  SAKAMOTO, Shuichi ,  TSUKAMOTO, Shin-ichi

    IPC分类号： C07D207/14 ,  A61K31/40

    CPC分类号： C07D207/14

    摘要： N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D 3 and/or D 4 receptor and are useful as a psychotropic, a schizophrenia-treating agent and the like, or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation thereof.
    (wherein each symbol in the formula has the following meaning,

    R 1 : hydrogen, lower alkyl, aralkyl, or cycloalkyl or cycloalkyl-lower alkyl having 3 to 8 ring atoms,
    R 2 : bicyclic or tricyclic bridged hydrocarbon ring of 4 to 16 ring atoms which may have lower alkyl,
    R 3 : lower alkoxy, amino or mono- or di-lower alkylamino,
    R 4 : hydrogen, halogen, lower alkyl which may have hydroxyl, lower alkoxy, cyano, nitro, amino, mono- or di-lower alkylamino, acyl or a group represented by -S(O) m -R 5 ,
    R 5 : lower alkyl, amino or mono- or di-lower alkylamino,
    m: 0, 1 or 2,
    X: a bond or a group represented by -O-, -S(O) n -, -NH- or -CONH-, and
    n: 0, 1 or 2,
    with the proviso that, when R 1 is cycloalky, the cases wherein X is -CONH-, R 3 is lower alkoxy and R 4 is halogen are excluded.)

    摘要翻译： 具有对多巴胺D3和/或D4受体具有强效和选择性拮抗作用并且可用作精神药物，精神分裂症治疗剂等的由以下通式（I）表示的N-（3-吡咯烷基）苯甲酰胺衍生物，或 其药学上可接受的盐或其药物制剂。 （其中式中的每个符号具有以下含义：R 1：氢，低级烷基，芳烷基或具有3至8个环原子的环烷基或环烷基 - 低级烷基，R 2：双环或三环桥连 具有4至16个环原子的烃环，其可具有低级烷基，R 3：低级烷氧基，氨基或单 - 或二 - 低级烷基氨基，R 4：氢，卤素，可具有羟基的低级烷基，低级烷氧基 ，氰基，硝基，氨基，一或二低级烷基氨基，酰基或由-S（O）m R 5表示的基团，R 5：低级烷基，氨基或单 - 或二 - 低级烷基氨基，m ：0,1或2，X：由-O - ， - S（O）n-，-NH-或-CONH-表示的键或基团，n：0,1或2，条件是， 当R 1为环烷基时，其中X为-CONH-，R 3为低级烷氧基且R 4为卤素的情况除外）

    NOVEL BISOXADIAZOLIDINE DERIVATIVE
    3.
    发明授权
    NOVEL BISOXADIAZOLIDINE DERIVATIVE 失效
    新型双二唑二唑衍生物

    公开(公告)号：EP0696585B1

    公开(公告)日：1998-12-16

    申请号：EP94913821.8

    申请日：1994-04-26

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： NIIGATA, Kunihiro ,  TAKAHASHI, Takumi ,  MARUYAMA, Tatsuya ,  SUZUKI, Takayuki ,  MAENO, Kyoichi ,  ONDA, Kenichi ,  KONTANI, Toru ,  NOSHIRO, Osamu ,  KOIKE, Reiko ,  SHIMAYA, Akiyoshi ,  IRIE, Jun

    IPC分类号： C07D271/06 ,  C07D413/14 ,  A61K31/41 ,  A61K31/44

    CPC分类号： C07D271/07 ,  C07D413/14

    摘要： A bisoxadiazolidinedione derivative of general formula (I) useful as an insulin-sensitivity improver, a pharmaceutically acceptable salt thereof, and a medicinal composition thereof, wherein (a) and (b) may be the same or different from each other and each represent an optionally substituted phenylene group, and L represents: (1) an oxygen atom, (2) a group of formula (II) (R1 being a hydrogen atom or a lower alkyl group), (3) a group of the formula: -S(O)¿n?- (n being 0, 1 or 2), (4) a group of the formula: -CO-, (5) a group of formula (III) or (IV) (R?2¿ being a hydrogen atom or a lower alkyl group), or (6) an alkylene or alkenylene group which may be substituted and interrupted by an oxygen atom and/or a sulfur atom, and the like.

    摘要翻译： 用作胰岛素敏感性改进剂的通式（I）的双恶二唑烷二酮衍生物，其药学上可接受的盐及其药用组合物，其中（a）和（b）可以彼此相同或不同，并且各自表示 （1）氧原子，（2）式（II）的基团（R 1为氢原子或低级烷基），（3）下式的基团：-S （O）n - （n为0,1或2），（4）式-CO-的基团，（5）式（III）或（IV）的基团 氢原子或低级烷基），或（6）可以被氧原子和/或硫原子取代和插入的亚烷基或亚烯基等。

    NOVEL BISOXADIAZOLIDINE DERIVATIVE
    5.
    发明公开
    NOVEL BISOXADIAZOLIDINE DERIVATIVE 失效
    新型双二唑二唑衍生物

    公开(公告)号：EP0696585A1

    公开(公告)日：1996-02-14

    申请号：EP94913821.8

    申请日：1994-04-26

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： NIIGATA, Kunihiro ,  TAKAHASHI, Takumi ,  MARUYAMA, Tatsuya ,  SUZUKI, Takayuki ,  MAENO, Kyoichi ,  ONDA, Kenichi ,  KONTANI, Toru ,  NOSHIRO, Osamu ,  KOIKE, Reiko ,  SHIMAYA, Akiyoshi ,  IRIE, Jun

    IPC分类号： C07D271/06 ,  C07D413/14 ,  A61K31/41 ,  A61K31/44

    CPC分类号： C07D271/07 ,  C07D413/14

    摘要： A bisoxadiazolidinedione derivative of general formula (I) useful as an insulin-sensitivity improver, a pharmaceutically acceptable salt thereof, and a medicinal composition thereof, wherein (a) and (b) may be the same or different from each other and each represent an optionally substituted phenylene group, and L represents: (1) an oxygen atom, (2) a group of formula (II) (R¹ being a hydrogen atom or a lower alkyl group), (3) a group of the formula: -S(O) n - (n being 0, 1 or 2), (4) a group of the formula: -CO-, (5) a group of formula (III) or (IV) (R² being a hydrogen atom or a lower alkyl group), or (6) an alkylene or alkenylene group which may be substituted and interrupted by an oxygen atom and/or a sulfur atom, and the like.

    摘要翻译： 用作胰岛素敏感性改进剂的通式（I）的双恶二唑烷二酮衍生物，其药学上可接受的盐及其药用组合物，其中（a）和（b）可以彼此相同或不同，并且各自表示 （1）氧原子，（2）式（II）的基团（R 1为氢原子或低级烷基），（3）下式的基团：-S （O）n-（n为0,1或2），（4）式-CO-的基团，（5）式（III）或（IV）的基团（R 2为氢原子或 低级烷基）或（6）可被氧原子和/或硫原子取代和插入的亚烷基或亚烯基等。