公开(公告)号：EP3118207A1

公开(公告)日：2017-01-18

申请号：EP15761774.7

申请日：2015-03-12

申请人： YAMASA CORPORATION

发明人： TANAKA, Hisaki ,  ISHIGE, Kazuya

IPC分类号： C07H21/02 ,  C07H1/00

摘要： Though 3',5'-cyclic diadenylic acid was conventionally provided only as a freeze-dried product, a solid material other than a freeze-dried product and a manufacturing method thereof is provided. By a step of adding acid to an aqueous solution of 3',5'-cyclic diadenylic acid so as to lower pH to 1 to 3, an inclusion compound of 3',5'-cyclic diadenylic acid can be obtained. Said manufacturing method is an extremely simple and easy method and does not need a special machine or the like.

摘要翻译： 以往只提供3'，5'-环状二烯酸作为冷冻干燥物，但提供冻干物以外的固体物质及其制造方法。 通过在3'，5'-环状二聚酸的水溶液中添加酸以将pH降低至1〜3的步骤，可以得到3'，5'-环状二聚酸的包合物。 所述制造方法是非常简单且容易的方法，并且不需要特殊的机器等。

公开(公告)号：EP3121188A1

公开(公告)日：2017-01-25

申请号：EP15759144.7

申请日：2015-02-27

申请人： YAMASA CORPORATION

发明人： TANAKA, Hisaki ,  ISHIGE, Kazuya

IPC分类号： C07H19/213

CPC分类号： C07H19/207 ,  C07H1/00 ,  C07H19/213

摘要： A crystal of free acid of 3',5'-cyclic diguanylic acid containing no metal salt with cobalt, magnesium or the like is provided. A method is sought for obtaining said crystal in a large amount and with ease. By a manufacturing method comprising a step of adding acid to an aqueous solution of 3',5'-cyclic diguanylic acid so as to lower pH to 1 to 3, crystals of 3',5'-cyclic diguanylic acid can be obtained in a large amount with ease. Said crystals are free acid crystals which do not contain a metal salt with cobalt, magnesium or the like.

摘要翻译： 提供不含金属盐与钴，镁等的3'，5'-环二
十二烷酸的游离酸结晶。 寻求大量且容易地获得所述晶体的方法。 通过包括向3'，5'-环二甘氨酸的水溶液中加酸以降低pH至1至3的步骤的制造方法，可以得到3'，5'-环二腺苷酸的晶体 大量轻松。 所述晶体是游离酸结晶，其不含与钴，镁等金属盐。

公开(公告)号：EP3118207B1

公开(公告)日：2020-08-05

申请号：EP15761774.7

申请日：2015-03-12

申请人： YAMASA CORPORATION

发明人： TANAKA, Hisaki ,  ISHIGE, Kazuya

IPC分类号： C07H21/02 ,  C07H1/00