公开(公告)号：EP2467135A2

公开(公告)日：2012-06-27

申请号：EP10757482.4

申请日：2010-08-19

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services And Development

发明人： CHEVION, Mordechai ,  VINOKUR, Vladimir ,  BERENSHTEIN, Eduard ,  ELIASHAR, Ron ,  BULVIK, Baruch

IPC分类号： A61K31/28 ,  A61K31/315 ,  A61P29/00 ,  A61P37/00 ,  A61P17/06 ,  A61P11/06 ,  A61P3/10 ,  A61P27/12

CPC分类号： A61K31/315 ,  A61K31/28 ,  A61K2300/00

摘要： The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.

公开(公告)号：EP0706391A1

公开(公告)日：1996-04-17

申请号：EP94921320.0

申请日：1994-06-17

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： CHEVION, Mordechai ,  BERENSHTEIN, Eduard

IPC分类号： A61K33 ,  C07C259

CPC分类号： A61K33/30 ,  C07C259/06

摘要： A pharmaceutical composition comprises a gallium complex of desferrioxamine or penicillamine as active ingredient therein, in combination with a pharmacologically acceptable carrier. The gallium desferrioxamine or gallium penicillamine complex are useful in the treatment of free radical-induced pathological conditions; the treatment of injury resulting from ischemic insult to the heart, brain or kidney; the treatment of thallasemia; the treatment of hemochromatosis; the treatment of Wilson disease; the treatment of paraquat toxicity; or for exchanging gallium for iron.