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1.发明授权RADIOLABELED IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND THEIR USE IN RADIOIMAGING AND RADIOTHERAPY 有权表皮生长因子受体酪氨酸激酶和放射性注明不可逆抑制剂它们在放射性成像和放射治疗
公开(公告)号：EP1411993B1
公开(公告)日：2010-05-05
申请号：EP02702703.6
申请日：2002-03-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
CPC分类号： A61K51/0459
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2.发明公开NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR-BINDING COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY 审中-公开新的表皮WACHSTUMKAKTOR受体配体的正电子发射断层扫描
公开(公告)号：EP1180034A1
公开(公告)日：2002-02-20
申请号：EP00930818.0
申请日：2000-05-19
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： MISHANI, Eyal , BONASERA, Thomas , ORTU, Giuseppina , ROZEN, Yulia , GAZIT, Aviv , LEVITZKI, Alexandra
IPC分类号： A61K31/517 , A61P17/06 , A61P35/00 , C07D239/94
CPC分类号： C07D239/94 , A61K51/0459
摘要： A radiolabeled compound of formula (I): is described R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, halo, haloalkyl, carboxy, carbalkoxy and salts thereof; and A, B, C and D are each independently selected from the group consisting of a hydrogen and an electon withdrawing group, provided that at least one of A, B, C and D is [18] fluorine.
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3.发明公开RADIOLABELED ANILINOQUINAZOLINES AND THEIR USE IN RADIOIMAGING AND RADIOTHERAPY 审中-公开放射性注明苯胺基及其使用无线电操作和放射治疗
公开(公告)号：EP1673110A2
公开(公告)日：2006-06-28
申请号：EP04770505.8
申请日：2004-09-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT CO., LTD.
IPC分类号： A61K51/04
CPC分类号： A61K51/0459 , A61K51/0463
摘要： Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.
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4.发明公开RADIOLABELED IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND THEIR USE IN RADIOIMAGING AND RADIOTHERAPY 有权表皮生长因子受体酪氨酸激酶和放射性注明不可逆抑制剂它们在放射性成像和放射治疗
公开(公告)号：EP1411993A2
公开(公告)日：2004-04-28
申请号：EP02702703.6
申请日：2002-03-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
CPC分类号： A61K51/0459
摘要： Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.
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