公开(公告)号：EP0040639A4

公开(公告)日：1982-03-22

申请号：EP80902298

申请日：1980-11-25

申请人： YOSHITOMI PHARMACEUTICAL

发明人： KAWAKITA TAKESHI ,  MURO TOMIO ,  SETOGUCHI MICHIHIDE

IPC分类号： A61K31/415 ,  A61K31/42 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5377 ,  A61P1/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/26 ,  A61P29/00 ,  C07D261/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D471/20

CPC分类号： C07D471/04 ,  C07D261/04 ,  C07D471/10

摘要： Isoxazole derivatives represented by the following general formula: (FORMULA) (wherein Ar represents a phenyl or pyridyl group optionally substituted by halogen or lower alkoxy, R1 represents a hydrogen atom, a lower alkyl group or a group of Ar, R2 represents a hydrogen atom or, when R1 and R2 are taken together, they form a carbon-to-carbon bond, and Am represents an amine residue selected from the following: (FORMULA) wherein R3 represents a hydrogen atom or a lower alkyl group, X1 and X2 each represent a hydrogen atom, a halogen atom or a trifluoromethyl group, and Y represents 0 or S) and the salts thereof. These are useful as psychotropic drugs and antimetics.

公开(公告)号：EP0125315A4

公开(公告)日：1985-06-26

申请号：EP83903564

申请日：1983-11-09

申请人： YOSHITOMI PHARMACEUTICAL

发明人： MURO TOMIO ,  TSUDA YOSHINAO ,  MISHINA TADASHI ,  OBATA MINORU ,  INUI JUN

IPC分类号： A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/505 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D239/34 ,  C07D277/20 ,  C07D277/34

CPC分类号： C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D239/34 ,  C07D277/34

摘要： Phenoxyaminopropanol derivatives represented by the general formula (I), wherein R represents 2-, 3- or 4-pyridyl, 2-pyrimidyl, 2-thiazolyl or 5-bromo-2-thiazolyl, R1 and R2 each represents H, lower alkyl, cycloalkyl, aralkyl or, when bound to each other, R1 and R2 represent a group forming a pyrrolidine or piperidine ring together with the adjacent nitrogen atom, and A represents alkylen containing 2 or 3 carbon atoms, and salts thereof. These are useful as heart-selective beta-blockers.

摘要翻译： 其中R表示2-，3-或4-吡啶基，2-嘧啶基，2-噻唑基或5-溴-2-噻唑基的通式（I）代表的苯氧基氨基丙醇衍生物，R1和R2各代表H，低级烷基， 环烷基，芳烷基或当彼此连接时，R1和R2代表与相邻的氮原子一起形成吡咯烷或哌啶环的基团，A代表含有2或3个碳原子的亚烷基及其盐。 这些作为心脏选择性β受体阻滞剂是有用的。