公开(公告)号：EP0995746A1

公开(公告)日：2000-04-26

申请号：EP98928630.7

申请日：1998-06-23

申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

发明人： HIRAYAMA, Fumihiro, Yoshitomi Phar. Ind., Ltd. ,  SANO, Mitsuharu, Yoshitomi Phar. Ind. Ltd. ,  SAKURAI, Nobuhiro, Yoshitomi Phar. Ind. Ltd. ,  YOKOYAMA, Yoshito, Yoshitomi Phar. Ind. Ltd.

IPC分类号： C07D413/04 ,  A61K31/535

CPC分类号： A61K31/5377 ,  A61K31/535

摘要： The present invention relates to an agent for the prophylaxis and treatment of diseases caused by Helicobacter infections, which comprises (S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoguinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof. The prophylactic and therapeutic agent of the present invention is effective even when used alone in a small dose for a short time, is almost free of problematic side effects such as tolerance and diarrhea, and is low toxic and capable of safe and ensured bacterial eradication. It is useful for the prophylaxis and treatment of diseases caused by Helicobacter infections, particularly, gastritis, gastric ulcer, duodenal ulcer, malignant lymphoma and gastric cancer.

摘要翻译： 本发明涉及一种用于由螺杆菌属感染引起的疾病的预防和治疗方法，其包括（S）-1-环丙基-1,4-二氢-7--A2-（N，N-二甲基氨基甲基）吗啉代OB 6的试剂 氟-8-甲氧基-4- oxoguinoline -3-羧酸或其药学上可接受的盐。 本发明的预防和治疗剂是有效的，即使当在小剂量在短时间内单独使用，几乎是无问题的副作用：如公差和腹泻，并且是低毒性的，并且能够安全并确保细菌根除。 它是用于治疗由幽门螺杆菌感染，尤其胃炎，胃溃疡，十二指肠溃疡，恶性淋巴瘤和胃癌引起的疾病的预防和治疗是有用的。