公开(公告)号：EP3320914A1

公开(公告)日：2018-05-16

申请号：EP17209271.0

申请日：2013-09-10

申请人： Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science

发明人： EISENBACH-SCHWARTZ, Michal ,  FRIEDMAN, Nir ,  BARUCH, Kuti ,  KUNIS, Gilad ,  CAHALON, Liora ,  ROSENZWEIG, Neta ,  DECZKOWSKA, Aleksandra

IPC分类号： A61K38/21 ,  A61K39/00 ,  A61K45/06 ,  C12N5/00 ,  A61P25/00 ,  A61P25/28 ,  A61K35/17 ,  C12N5/0783 ,  C12N15/117

CPC分类号： A61K39/0007 ,  A61K35/17 ,  A61K38/217 ,  A61K45/06 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/57 ,  A61P25/28 ,  C07K16/2878 ,  C07K2317/76 ,  C12N5/0636 ,  C12N15/117 ,  C12N2310/17 ,  C12N2320/30 ,  C12N2501/2304 ,  C12N2501/2306 ,  C12N2501/231 ,  C12N2501/2317 ,  C12N2501/24 ,  C12N2501/25 ,  A61K2300/00

摘要： A method for treating a disease, disorder, condition or injury of the Central Nervous System (CNS) in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of an active ingredient, such as a non-encephalitogenic or weakly encephalitogenic combination of a Th1 adjuvant and a CNS-specific antigen, causing activation of the choroid plexus of said subject and maintaining said activation by reducing immunosuppression and establishing Th1-type immune response at the choroid plexus thus allowing either anti-inflammatory immune cells or immune cells which acquire a healing phenotype at the cerebrospinal fluid to pass through the choroid plexus, and accumulate at a site of damage in the CNS caused by said disease, disorder, condition or injury is provided.

摘要翻译： 一种治疗有需要的受试者的中枢神经系统（CNS）的疾病，病症，病症或损伤的方法，其包括向所述受试者施用治疗有效量的活性成分，例如非脑炎或弱致脑炎 Th1佐剂和CNS特异性抗原的组合，引起所述受试者脉络丛的激活，并通过减少免疫抑制并在脉络丛中建立Th1型免疫应答来维持所述活化，从而使得抗炎免疫细胞或免疫细胞 其在脑脊液获得愈合表型以穿过脉络丛，并且积聚在由所述疾病，病症，病症或损伤引起的CNS损伤部位处。