专利检索 ap:("Yissum Research Development Company of the Hebrew University of Jerusalem") AND inv:"FRIDKIN, Gil" 第 1 页

1.

发明公开
LABELLED SOMATOSTATIN ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION 审中-公开
标题翻译： BY金属复合物的形成环化突出生长抑素类似物-FRAME

公开(公告)号：EP1539216A2

公开(公告)日：2005-06-15

申请号：EP03730462.3

申请日：2003-06-24

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem

发明人： BONASERA, Thomas, A. , FRIDKIN, Gil , GILON, Chaim

IPC分类号： A61K38/16

CPC分类号： C07D403/14 , A61K38/00 , A61K51/083 , A61K51/088 , C07K14/655

摘要： Novel diagnostic and therapeutic peptides which are somatostatin analogs backbone cyclized through metal complexation, having improved somatostin receptor subtype affinity and selectivity are disclosed. The backbone cyclized peptide analogs disclosed possess unique and superior properties over other analogs, such as chemical and metabolic stability, selectivity, increased bioavailability and improved pharmacokinetics. Pharmaceutical compositions comprising the backbone cyclized somatostin analogs and radiolabelled analogs, reagents for synthesizing same, and methods of using such compositions for diagnostic and therapeutic purposes are also disclosed.