公开(公告)号：EP2498754B1

公开(公告)日：2018-06-06

申请号：EP10738041.2

申请日：2010-06-24

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.

发明人： GARTI, Nissim ,  ASERIN, Abraham ,  LIBSTER, Dima ,  MISHRAKI, Tehila ,  AMAR-YULI, Idit ,  BITAN-CHERVKOVSKY, Liron

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K38/13 ,  A61K38/28 ,  A61K38/31

CPC分类号： A61K9/1274 ,  A61K9/0014 ,  A61K9/0053 ,  A61K38/13 ,  A61K38/28 ,  A61K38/31 ,  A61K2300/00

摘要： Reverse hexagonal mesophase (HII) liquid crystals provide multi-component hexagonal systems for use in solubilizing and/or protecting from degradation one or more bio-macromolecule and/or active material, and relates to therapeutic and non-therapeutic applications, such as an oral delivery system, where the mesophase is adapted for oral administration. The present invention provides the formation of mesophase systems of ternary glycerol monooleate (GMO)/water combinations which comprise at least one triglyceride or an equivalent thereof. At least one biomacromolecule or drug is incorporated in the mesophase of a pharmaceutical composition or oral delivery system.

公开(公告)号：EP2498754A2

公开(公告)日：2012-09-19

申请号：EP10738041.2

申请日：2010-06-24

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.

发明人： GARTI, Nissim ,  ASERIN, Abraham ,  LIBSTER, Dima ,  MISHRAKI, Tehila ,  AMAR-YULI, Idit ,  BITAN-CHERVKOVSKY, Liron

IPC分类号： A61K9/127

CPC分类号： A61K9/1274 ,  A61K9/0014 ,  A61K9/0053 ,  A61K38/13 ,  A61K38/28 ,  A61K38/31 ,  A61K2300/00

摘要： Reverse hexagonal mesophase (HII) liquid crystals are provided and relating therapeutic and non-therapeutic applications are demonstrated.

摘要翻译： 提供了反向六方晶中间相（HII）液晶，并且证明了相关的治疗和非治疗应用。