公开(公告)号：EP0907653A1

公开(公告)日：1999-04-14

申请号：EP97928361.0

申请日：1997-06-24

申请人： ZENECA LIMITED

发明人： GALLAGHER, Timothy, Charles ,  HALES, Neil, James ,  WISEDALE, Richard ,  PLANCHENAULT, Denis

IPC分类号： C07D499 ,  A61K31 ,  C07D263

CPC分类号： C07D499/88 ,  C07D499/00 ,  Y02P20/55

摘要： The invention provides a process for the preparation of compounds of formula (I) wherein R?1, R2, R3, R4 and R5¿ are as defined in the specification; and wherein any functional groups are optionally protected; and salts thereof; which process includes the step of reacting the intermediate formed by heating a compound of formula (II), in an inert solvent, with a compound of the formula S=C(R3)R4 wherein R?1, R2, R3, R4 and R5¿ are as defined in the specification and functional groups are optionally protected; and thereinafter, if necessary, removing any protecting groups. The compounds of the formula (I) are useful as intermediates in the preparation of penems and may possess antibacterial properties and/or inhibit β-lactamase in their own right.