公开(公告)号：EP4285918A1

公开(公告)日：2023-12-06

申请号：EP21922129.8

申请日：2021-05-27

申请人： ZHEJIANG NOVUS PHARMACEUTICALS CO., LTD. ,  Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

发明人： YUAN, Xiying ,  WANG, Weibao ,  WU, Guofeng ,  YE, Lili ,  WU, Jiali ,  CAI, Jingjing ,  PAN, Yibin ,  ZHA, Juan ,  GAO, Zhongming ,  SUN, Qiming ,  HE, Yimin ,  WANG, Zuoliang ,  PING, Jianhong

IPC分类号： A61K38/12 ,  A61K9/14 ,  A61K9/19 ,  A61K47/02 ,  A61P31/04

摘要： The present invention provides a high-stability daptomycin composition for injection and preparation method therefor and use thereof. The daptomycin composition for injection comprises daptomycin and a pharmaceutically acceptable carrier, and the pharmaceutically acceptable carrier contains a divalent metal salt, a pH regulator, and an osmotic pressure regulator; and the molar ratio of daptomycin to divalent metal salt in the daptomycin composition for injection is 1: 1.0 to 1: 3.5. The daptomycin composition for injection of the present invention significantly improves the stability of the preparation, facilitates the storage and transportation of the preparation at room temperature, and ensures the safety of drug use; And the preparation method of the present invention has advantages such as green environmental protection, suitability for industrialization.

公开(公告)号：EP3915392A1

公开(公告)日：2021-12-01

申请号：EP20744772.3

申请日：2020-01-22

申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

发明人： XU, Xinde ,  WANG, Zuoliang ,  LIU, Aiqin ,  XIE, Tian ,  YU, Leiming ,  HOU, Guozhi ,  SUN, Qiming ,  SHI, Yongsheng

IPC分类号： A23L2/39

摘要： The present invention provides a solid beverage containing barley leaves, comprising the following components: 15-60 wt.% of a barley leaf micro-powder, 10-50 wt.% of xylitol granules, 5-20 wt.% of a matcha powder, 1-10 wt.% of inulin, 0.5-4.0 wt.% of a konjac powder, 0.2-3.0 wt.% of silicon dioxide, and 0.1-3.0 wt.% of sucralose. The present invention also relates to a method for preparing the solid beverage, comprising the following steps: mixing a barley leaf micro-powder, inulin, a konjac powder and matcha powder, and then performing wet granulation on same to obtain granulated powders; passing the granulated powders through a 20-mesh sieve after drying same to obtain whole granules; and uniformly mixing the whole granules with xylitol granules, sucralose and silicon dioxide, and then sub-packaging same, so as to obtain the solid beverage. The solid beverage is easy and fast to dissolve, does not separate, and tastes refined and smooth.