-
公开(公告)号：EP0737068B1
公开(公告)日：2004-09-15
申请号：EP95905361.2
申请日：1994-12-14
申请人： ZymoGenetics, Inc.
IPC分类号： A61K31/35 , A61K31/40 , A61K31/445 , A61P17/00
CPC分类号： A61K31/40 , A61K31/35 , A61K31/445 , Y10S514/861 , Y10S514/863
摘要： Methods and pharmaceutical compositions for the treatment of dermatitis are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments, including oral and topical medicaments, which are administered to a patient suffering from dermatitis. The methods and compositions are particularly useful in the treatment of conditions characterized by hyperproliferation of keratinocytes, such as psoriasis.
-
公开(公告)号：EP0977571A1
公开(公告)日：2000-02-09
申请号：EP99908196.1
申请日：1999-02-17
申请人： ZymoGenetics, Inc.
发明人： PIGGOTT, James, R.
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： Piperazine derivatives useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disorder, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery and post-dental implantation.
-
公开(公告)号：EP0737068A1
公开(公告)日：1996-10-16
申请号：EP95905361.0
申请日：1994-12-14
申请人： ZymoGenetics, Inc.
CPC分类号： A61K31/40 , A61K31/35 , A61K31/445 , Y10S514/861 , Y10S514/863
摘要： Methods and pharmaceutical compositions for the treatment of dermatitis are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments, including oral and topical medicaments, which are administered to a patient suffering from dermatitis. The methods and compositions are particularly useful in the treatment of conditions characterized by hyperproliferation of keratinocytes, such as psoriasis.
-
公开(公告)号：EP0567562B1
公开(公告)日：1996-03-13
申请号：EP92904367.7
申请日：1992-01-14
申请人： ZYMOGENETICS, INC.
IPC分类号： C07K14/605 , C12N15/16
CPC分类号： C07K14/605
摘要： Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.
-
公开(公告)号：EP0688215A1
公开(公告)日：1995-12-27
申请号：EP94911467.0
申请日：1994-03-07
申请人： ZYMOGENETICS, INC.
发明人： PIGGOTT, James, R.
摘要： Methods and pharmaceutical compositions for the treatment of dermatitis are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments, including oral and topical medicaments, which are administered to a patient suffering from dermatitis. The methods and compositions are particularly useful in the treatment of conditions characterized by hyperproliferation of keratinocytes, such as psoriasis.
-
6.发明公开
公开(公告)号：EP0658170A1
公开(公告)日：1995-06-21
申请号：EP93920400.0
申请日：1993-08-27
申请人： ZYMOGENETICS, INC.
CPC分类号： C07K14/605
摘要： Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.
摘要翻译： 提供了通过使用重组DNA技术检测胰高血糖素拮抗剂的方法。 简而言之，在合适的宿主细胞内表达胰高血糖素类似物后，在天然胰高血糖素存在下将类似物暴露于与应答途径偶联的胰高血糖素受体。 由胰高血糖素类似物与胰高血糖素受体的结合引起的对反应途径的刺激的减少相对于单独使用天然胰高血糖素刺激反应途径表明存在胰高血糖素拮抗剂。 还提供了通过该方法鉴定和分离的胰高血糖素拮抗剂。
-
公开(公告)号：EP0567562A1
公开(公告)日：1993-11-03
申请号：EP92904367.0
申请日：1992-01-14
申请人： ZYMOGENETICS, INC.
CPC分类号： C07K14/605
摘要： On décrit des procédés de détection d'antagonistes de glucagon à l'aide de techniques de recombinaison de l'ADN. En bref, subséquemment à l'expression d'analogues de glucagon dans des cellules hôtes appropriées, les analogues sont exposés à un récepteur de glucagon couplé à un processus de réponse en présence du glucagon naturel. Une réduction observée dans la stimulation du processus de réponse produite par la liaison de l'analogue de glucagon au récepteur de glucagon, par rapport à la stimulation du processus de réponse par le glucagon naturel uniquement, indique la présence d'un antagoniste de glucagon. On décrit aussi des antagonistes de glucagon identifiés et isolés au moyen de ces procédés.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.012 秒)
