公开(公告)号：EP2621909A1

公开(公告)日：2013-08-07

申请号：EP11761348.9

申请日：2011-09-22

申请人： ZaCh System S.p.A.

发明人： COTARCA, Livius ,  VERZINI, Massimo ,  MELOTTO, Elisa ,  MICHIELETTO, Ivan ,  MELLONI, Alfonso ,  MARAGNI, Paolo ,  VOLPICELLI, Raffaella ,  ANDRETTO, Mauro ,  COLLI, Corrado

IPC分类号： C07D239/69

CPC分类号： C07D239/69 ,  C07C31/202

摘要： The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.