公开(公告)号：EP1838670B1

公开(公告)日：2009-10-14

申请号：EP05815876.7

申请日：2005-12-05

申请人： ZaCh System S.p.A.

发明人： TREPAT GUIXER, Elisenda, Zambon SA ,  MUNOZ ALVAREZ, Anna, Zambon SA ,  POMARES MARCO, Marta, Zambon SA ,  MARQUILLAS OLONDRIZ, Francisco, Zambon SA

IPC分类号： C07D209/88 ,  A61K31/403 ,  A61P9/04 ,  A61P9/12

CPC分类号： C07D209/88

摘要： The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.

公开(公告)号：EP1838670A1

公开(公告)日：2007-10-03

申请号：EP05815876.7

申请日：2005-12-05

申请人： ZaCh System S.p.A.

发明人： TREPAT GUIXER, Elisenda, Zambon SA ,  MUNOZ ALVAREZ, Anna, Zambon SA ,  POMARES MARCO, Marta, Zambon SA ,  MARQUILLAS OLONDRIZ, Francisco, Zambon SA

IPC分类号： C07D209/88 ,  A61K31/403 ,  A61P9/04 ,  A61P9/12

CPC分类号： C07D209/88

摘要： The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.