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1.发明公开METHOD FOR MANUFACTURING CRYSTALLINE FORM I OF CLOPIDOGREL HYDROGEN SULPHATE 无效过程为晶型Ⅰ氯吡格雷HYDROGENSULPHAT的制备
公开(公告)号：EP1554284A1
公开(公告)日：2005-07-20
申请号：EP03750270.5
申请日：2003-08-26
申请人： ZENTIVA, A.S.
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with Cl-C4 carboxylic acids, or optionally of mixtures thereof.
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2.发明授权METHOD FOR MANUFACTURING CRYSTALLINE FORM I OF CLOPIDOGREL HYDROGEN SULPHATE 无效过程为晶型Ⅰ氯吡格雷HYDROGENSULPHAT的制备
公开(公告)号：EP1554284B1
公开(公告)日：2008-10-22
申请号：EP03750270.5
申请日：2003-08-26
申请人： Zentiva, a.s.
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with Cl-C4 carboxylic acids, or optionally of mixtures thereof.
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