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    ORALLY ADMINISTRABLE TABLET FOR INTESTINAL LAVAGE
    1.
    发明公开
    ORALLY ADMINISTRABLE TABLET FOR INTESTINAL LAVAGE 有权
    ORAL VERABREICHTE TABLETTE ZUR DARMREINIGUNG

    公开(公告)号：EP2476424A1

    公开(公告)日：2012-07-18

    申请号：EP10811523.9

    申请日：2010-08-27

    申请人： Zeria Pharmaceutical Co., Ltd.

    发明人： NOMURA, Masafumi ,  NISHIYAMA, Tetsuyuki ,  ICHIKAWA, Mari ,  FUKAYA, Kyoko

    IPC分类号： A61K33/42 ,  A61K9/20 ,  A61K31/717 ,  A61P1/10 ,  A61K49/00

    CPC分类号： A61K33/42 ,  A61K9/2054 ,  A61K31/717 ,  A61K45/06 ,  A61K2300/00

    摘要： To provide a peroral tablet for bowel cleansing which leaves no remains in the intestinal tract after bowel cleansing, which exhibits a dissolution property equivalent to that of conventional sodium phosphate-containing tablets including crystalline cellulose, and which is a small-size agent readily taken by a subject.
    The peroral tablet for bowel cleansing containing the following ingredients (A) and (B):
    (A) 80 to 95 mass% of sodium phosphate, and
    (B) (B1) 7 to 11 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 350 µm and whose 2-mass% aqueous solution has a viscosity of 2.0 to 10.0 mPa·s,
    (B2) 5 to 13 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 150 µm and whose 2-mass% aqueous solution has a viscosity of 3.0 to 5.9 mPa·s, or
    (B3) 7 to 11 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 150 µm and whose 2-mass% aqueous solution has a viscosity of 6.0 to 4,000 mPa·s, and
    having a water-insoluble ingredient content of 5 mass% or less.

    摘要翻译： 提供肠道清洁的口服片剂，其在肠清洗后没有留下肠道残留物，其显示出与包含结晶纤维素的常规含磷酸钠片剂相当的溶解性能，并且其是容易被 课程。 含有以下成分（A）和（B）的肠溶清洁口服片剂：（A）80〜95质量％的磷酸钠，（B）（B1）7〜11质量％的具有这样的粒子的羟丙基纤维素 粒径为99％的颗粒通过开孔为350μm的网，其2质量％的水溶液的粘度为2.0〜10.0mPa·s，（B2）为5〜13质量％的羟丙基纤维素 其粒径为99％以上的颗粒通过开孔为150μm的网，其2质量％的水溶液的粘度为3.0〜5.9mPa·s，或（B3）7〜 粒径为99％以下的羟丙基纤维素11质量％通过开孔为150μm的网眼，其2质量％的水溶液的粘度为6.0〜4000mPa·s， 并且具有5质量％以下的水不溶性成分含量。